EC number:1.14.19.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.4 | ||
|---|---|---|---|
| Description: | Acyl-lipid (11-3)-desaturase. | ||
| Alternative Name: |
SLD. Delta(8)-desaturase. Acyl-lipid 8-desaturase. | ||
| Prosite: | PDOC00170; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.4 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.4 |
| KEGG Enzyme Link: | KEGG1.14.19.4 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.4 |
| ExPASy Enzyme Link: | ExPASy1.14.19.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.4 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.4 |
EC number:1.14.19.4
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46796 | 2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP | 2007 Mar | 17291553 |
| The Delta8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids. | Wallis JG, Browse J | 1999 May 15 | 10328826 |
| RHEA:46792 | 2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP | 2007 Mar | 17291553 |
| The Delta8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids. | Wallis JG, Browse J | 1999 May 15 | 10328826 |