EC number:1.14.19.44
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.44 |
|---|---|
| Description: | Acyl-CoA (8-3)-desaturase. |
| Alternative Name: |
Acyl-CoA 5-desaturase (methylene-interrupted). |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.44 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.44 |
| KEGG Enzyme Link: | KEGG1.14.19.44 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.44 |
| ExPASy Enzyme Link: | ExPASy1.14.19.44 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.44 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.44 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.44 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.44 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.44 |
EC number:1.14.19.44
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46424 | (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. | Leonard AE, Kelder B, Bobik EG, Chuang LT, Parker-Barnes JM, Thurmond JM, Kroeger PE, Kopchick JJ, Huang YS, Mukerji P | 2000 May 1 | 10769175 |
| Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. | Cho HP, Nakamura M, Clarke SD | 1999 Dec 24 | 10601301 |
| Metabolic engineering of Saccharomyces cerevisiae for production of Eicosapentaenoic Acid, using a novel {Delta}5-Desaturase from Paramecium tetraurelia. | Tavares S, Grotkjær T, Obsen T, Haslam RP, Napier JA, Gunnarsson N | 2011 Mar | 21193673 |
| Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan. | Tripodi KE, Buttigliero LV, Altabe SG, Uttaro AD | 2006 Jan | 16403015 |
| RHEA:46420 | (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. | Leonard AE, Kelder B, Bobik EG, Chuang LT, Parker-Barnes JM, Thurmond JM, Kroeger PE, Kopchick JJ, Huang YS, Mukerji P | 2000 May 1 | 10769175 |
| Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. | Cho HP, Nakamura M, Clarke SD | 1999 Dec 24 | 10601301 |
| Metabolic engineering of Saccharomyces cerevisiae for production of Eicosapentaenoic Acid, using a novel {Delta}5-Desaturase from Paramecium tetraurelia. | Tavares S, Grotkjær T, Obsen T, Haslam RP, Napier JA, Gunnarsson N | 2011 Mar | 21193673 |
| Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan. | Tripodi KE, Buttigliero LV, Altabe SG, Uttaro AD | 2006 Jan | 16403015 |