EC number:1.14.19.47
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.47 |
|---|---|
| Description: | Acyl-lipid (9-3)-desaturase. |
| Alternative Name: |
Delta(6)-desaturase. Acyl-lipid 6-desaturase. |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.47 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.47 |
| KEGG Enzyme Link: | KEGG1.14.19.47 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.47 |
| ExPASy Enzyme Link: | ExPASy1.14.19.47 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.47 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.47 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.47 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.47 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.47 |
EC number:1.14.19.47
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46288 | (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of a novel delta 6-acyl-group desaturase by targeted gene disruption in Physcomitrella patens. | Girke T, Schmidt H, Zähringer U, Reski R, Heinz E | 1998 Jul | 9744093 |
| Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco. | Sayanova O, Smith MA, Lapinskas P, Stobart AK, Dobson G, Christie WW, Shewry PR, Napier JA | 1997 Apr 15 | 9108131 |
| A bifunctional delta-fatty acyl acetylenase/desaturase from the moss Ceratodon purpureus. A new member of the cytochrome b5 superfamily. | Sperling P, Lee M, Girke T, Zähringer U, Stymne S, Heinz E | 2000 Jun | 10848999 |
| RHEA:46284 | 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of a novel delta 6-acyl-group desaturase by targeted gene disruption in Physcomitrella patens. | Girke T, Schmidt H, Zähringer U, Reski R, Heinz E | 1998 Jul | 9744093 |
| Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco. | Sayanova O, Smith MA, Lapinskas P, Stobart AK, Dobson G, Christie WW, Shewry PR, Napier JA | 1997 Apr 15 | 9108131 |
| A bifunctional delta-fatty acyl acetylenase/desaturase from the moss Ceratodon purpureus. A new member of the cytochrome b5 superfamily. | Sperling P, Lee M, Girke T, Zähringer U, Stymne S, Heinz E | 2000 Jun | 10848999 |