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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

ID:	1.14.19.53
Description:	All-trans-retinol 3,4-desaturase.
Alternative Name:	CYP27C1.

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UniProtKB Enzyme Link:	UniProtKB 1.14.19.53
BRENDA Enzyme Link:	BRENDA 1.14.19.53
KEGG Enzyme Link:	KEGG1.14.19.53
BioCyc Enzyme Link:	BioCyc 1.14.19.53
ExPASy Enzyme Link:	ExPASy1.14.19.53
EC2PDB Enzyme Link:	EC2PDB 1.14.19.53
ExplorEnz Enzyme Link:	ExplorEnz 1.14.19.53
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.19.53
IntEnz Enzyme Link:	IntEnz 1.14.19.53
MEDLINE Enzyme Link:	MEDLINE 1.14.19.53

RHEA:50292	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]
RULE(radius=1)	[:1]-[CH2;+0:2]-[CH2;+0:3]-[:4].[:5]-[Fe;H0;+0:6]-[:7].[:8]-[Fe;H0;+0:9]-[:10].[H+;H0:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[CH;+0:2]=[CH;+0:3]-[:4].[:5]-[Fe+;H0:6]-[:7].[:8]-[Fe+;H0:9]-[:10].[OH2;+0:13].[OH2;+0:14]
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Title	Authors	Date	PubMed ID
Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.	Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP	2016 May	27059013
Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.	Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC	2015 Dec 7	26549260