EC number:1.14.20.10

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
ID:1.14.20.10
Description:Tyrosine isonitrile desaturase/decarboxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.20.10
BRENDA Enzyme Link: BRENDA 1.14.20.10
KEGG Enzyme Link: KEGG1.14.20.10
BioCyc Enzyme Link: BioCyc 1.14.20.10
ExPASy Enzyme Link: ExPASy1.14.20.10
EC2PDB Enzyme Link: EC2PDB 1.14.20.10
ExplorEnz Enzyme Link: ExplorEnz 1.14.20.10
PRIAM enzyme-specific profiles Link: PRIAM 1.14.20.10
IntEnz Enzyme Link: IntEnz 1.14.20.10
MEDLINE Enzyme Link: MEDLINE 1.14.20.10

EC number:1.14.20.10

MSA:

1.14.20.10;
Phylogenetic Tree:

1.14.20.10;
Uniprot:
M-CSA:
RHEA:56692 (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate
RULE(radius=1) [*:1]-[CH;+0:2](-[CH2;+0:3]-[*:4])-[C;H0;+0:5](=[*:6])-[OH;+0:7].[*:8]=[C;H0;+0:9](-[OH;+0:10])-[C;H0;+0:11](=[*:12])-[*:13].[H+;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:12]=[C;H0;+0:11](-[*:13])-[OH;+0:15].[*:6]=[C;H0;+0:5]=[O;H0;+0:7].[*:8]=[C;H0;+0:9]=[O;H0;+0:10].[OH2;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products.Zhu J, Lippa GM, Gulick AM, Tipton PA2015 Apr 2825866990
Small molecule perimeter defense in entomopathogenic bacteria.Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J2012 Jul 322711807