EC number:1.14.20.11

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
ID:1.14.20.11
Description:3-((Z)-2-isocyanoethenyl)-1H-indole synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.20.11
BRENDA Enzyme Link: BRENDA 1.14.20.11
KEGG Enzyme Link: KEGG1.14.20.11
BioCyc Enzyme Link: BioCyc 1.14.20.11
ExPASy Enzyme Link: ExPASy1.14.20.11
EC2PDB Enzyme Link: EC2PDB 1.14.20.11
ExplorEnz Enzyme Link: ExplorEnz 1.14.20.11
PRIAM enzyme-specific profiles Link: PRIAM 1.14.20.11
IntEnz Enzyme Link: IntEnz 1.14.20.11
MEDLINE Enzyme Link: MEDLINE 1.14.20.11

EC number:1.14.20.11

MSA:

1.14.20.11;
Phylogenetic Tree:

1.14.20.11;
Uniprot:
M-CSA:
RHEA:56700 (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate
RULE(radius=1) [*:1]-[CH;+0:2](-[CH2;+0:3]-[*:4])-[C;H0;+0:5](=[*:6])-[OH;+0:7].[*:8]=[C;H0;+0:9](-[OH;+0:10])-[C;H0;+0:11](=[*:12])-[*:13].[H+;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:12]=[C;H0;+0:11](-[*:13])-[OH;+0:15].[*:6]=[C;H0;+0:5]=[O;H0;+0:7].[*:8]=[C;H0;+0:9]=[O;H0;+0:10].[OH2;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua.Hillwig ML, Zhu Q, Liu X2014 Feb 2124180436
In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate.Chang WC, Sanyal D, Huang JL, Ittiamornkul K, Zhu Q, Liu X2017 Mar 328212039