EC number:1.14.20.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated |
| ID: | 1.14.20.12 |
|---|---|
| Description: | 3-((E)-2-isocyanoethenyl)-1H-indole synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.20.12 |
| BRENDA Enzyme Link: | BRENDA 1.14.20.12 |
| KEGG Enzyme Link: | KEGG1.14.20.12 |
| BioCyc Enzyme Link: | BioCyc 1.14.20.12 |
| ExPASy Enzyme Link: | ExPASy1.14.20.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.20.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.20.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.20.12 |
| IntEnz Enzyme Link: | IntEnz 1.14.20.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.20.12 |
EC number:1.14.20.12
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56704 | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6].[*:7]=[C;H0;+0:8](-[OH;+0:9])-[CH;+0:10](-[CH2;+0:11]-[c;H0;+0:12]1:[cH;+0:13]:[nH;+0:14]:[c;H0;+0:15]2:[cH;+0:16]:[cH;+0:17]:[cH;+0:18]:[cH;+0:19]:[c;H0;+0:20]:1:2)-[N+;H0:21]#[C-;H0:22].[H+;H0:23].[O;H0;+0:24]=[O;H0;+0:25]>>[*:5]=[C;H0;+0:4](-[*:6])-[OH;+0:24].[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:7]=[C;H0;+0:8]=[O;H0;+0:9].[OH2;+0:25] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. | Brady SF, Clardy J | 2005 Nov 4 | 16206308 |
| In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate. | Chang WC, Sanyal D, Huang JL, Ittiamornkul K, Zhu Q, Liu X | 2017 Mar 3 | 28212039 |