EC number:1.14.20.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated |
| ID: | 1.14.20.3 |
|---|---|
| Description: | (5R)-carbapenem-3-carboxylate synthase. |
| Cath: | 3.60.130.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.20.3 |
| BRENDA Enzyme Link: | BRENDA 1.14.20.3 |
| KEGG Enzyme Link: | KEGG1.14.20.3 |
| BioCyc Enzyme Link: | BioCyc 1.14.20.3 |
| ExPASy Enzyme Link: | ExPASy1.14.20.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.20.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.20.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.20.3 |
| IntEnz Enzyme Link: | IntEnz 1.14.20.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.20.3 |
EC number:1.14.20.3
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:36611 | (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[C;H0;+0:9](=[*:10])-[*:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:10]=[C;H0;+0:9](-[*:11])-[OH;+0:12].[*:6]=[C;H0;+0:7]=[O;H0;+0:8].[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study. | Borowski T, Broclawik E, Schofield CJ, Siegbahn PE | 2006 Apr 30 | 16521121 |
| The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase. | Topf M, Sandala GM, Smith DM, Schofield CJ, Easton CJ, Radom L | 2004 Aug 18 | 15303862 |
| Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). | Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ | 2004 Jun 7 | 15174175 |
| Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem. | Stapon A, Li R, Townsend CA | 2003 Dec 24 | 14677956 |
| Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. | Stapon A, Li R, Townsend CA | 2003 Jul 16 | 12848554 |
| Crystal structure of carbapenem synthase (CarC). | Clifton IJ, Doan LX, Sleeman MC, Topf M, Suzuki H, Wilmouth RC, Schofield CJ | 2003 Jun 6 | 12611886 |