EC number:1.14.20.6
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated |
| ID: | 1.14.20.6 | ||
|---|---|---|---|
| Description: | Flavonol synthase. | ||
| Alternative Name: |
FLS. Flavonoid 2-oxoglutarate-dependent dioxygenase. | ||
| Prosite: | PDOC51471; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.20.6 |
| BRENDA Enzyme Link: | BRENDA 1.14.20.6 |
| KEGG Enzyme Link: | KEGG1.14.20.6 |
| BioCyc Enzyme Link: | BioCyc 1.14.20.6 |
| ExPASy Enzyme Link: | ExPASy1.14.20.6 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.20.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.20.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.20.6 |
| IntEnz Enzyme Link: | IntEnz 1.14.20.6 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.20.6 |
EC number:1.14.20.6
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21088 | 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate |
| RULE(radius=1) | [*:1]:[c;H0;+0:2](:[*:3])-[CH;+0:4]1-[O;H0;+0:5]-[*:6]:[*:7]-[C;H0;+0:8](=[*:9])-[CH;+0:10]-1-[*:11].[*:12]=[C;H0;+0:13](-[OH;+0:14])-[C;H0;+0:15](=[*:16])-[*:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]:[c;H0;+0:2](:[*:3])-[c;H0;+0:4]1:[o;H0;+0:5]:[*:6]:[*:7]:[c;H0;+0:8](=[*:9]):[c;H0;+0:10]:1-[*:11].[*:16]=[C;H0;+0:15](-[*:17])-[OH;+0:18].[*:12]=[C;H0;+0:13]=[O;H0;+0:14].[OH2;+0:19] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley. | Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R | 2003 Jun 5 | 12782296 |
| Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase. | Turnbull JJ, Nakajima J, Welford RW, Yamazaki M, Saito K, Schofield CJ | 2004 Jan 9 | 14570878 |
| Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase. | Lukacin R, Wellmann F, Britsch L, Martens S, Matern U | 2003 Feb | 12620339 |
| Functional expression and mutational analysis of flavonol synthase from Citrus unshiu. | Wellmann F, Lukacin R, Moriguchi T, Britsch L, Schiltz E, Matern U | 2002 Aug | 12180990 |