EC number:1.14.20.9
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated |
| ID: | 1.14.20.9 |
|---|---|
| Description: | Tyrosine isonitrile desaturase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.20.9 |
| BRENDA Enzyme Link: | BRENDA 1.14.20.9 |
| KEGG Enzyme Link: | KEGG1.14.20.9 |
| BioCyc Enzyme Link: | BioCyc 1.14.20.9 |
| ExPASy Enzyme Link: | ExPASy1.14.20.9 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.20.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.20.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.20.9 |
| IntEnz Enzyme Link: | IntEnz 1.14.20.9 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.20.9 |
EC number:1.14.20.9
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56688 | (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[C;H0;+0:9](=[*:10])-[*:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:10]=[C;H0;+0:9](-[*:11])-[OH;+0:12].[*:6]=[C;H0;+0:7]=[O;H0;+0:8].[OH2;+0:13] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products. | Zhu J, Lippa GM, Gulick AM, Tipton PA | 2015 Apr 28 | 25866990 |
| Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. | Drake EJ, Gulick AM | 2008 Dec 5 | 18824174 |
| Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa. | Clarke-Pearson MF, Brady SF | 2008 Oct | 18689486 |