EC number:1.14.99.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.99 Miscellaneous |
| ID: | 1.14.99.1 |
|---|---|
| Description: | Prostaglandin-endoperoxide synthase. |
| Alternative Name: |
Prostaglandin synthetase. Prostaglandin synthase. Prostaglandin G/H synthase. PG synthetase. |
| Cath: | 1.10.640.10; 2.10.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.99.1 |
| BRENDA Enzyme Link: | BRENDA 1.14.99.1 |
| KEGG Enzyme Link: | KEGG1.14.99.1 |
| BioCyc Enzyme Link: | BioCyc 1.14.99.1 |
| ExPASy Enzyme Link: | ExPASy1.14.99.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.99.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.99.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.99.1 |
| IntEnz Enzyme Link: | IntEnz 1.14.99.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.99.1 |
EC number:1.14.99.1
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23728 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2 |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[CH;+0:3]-[CH2;+0:4]-[CH;+0:5]=[CH;+0:6]-[*:7]-[CH;+0:8]=[CH;+0:9]-[*:10].[O;H0;+0:11]=[O;H0;+0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[OH;+0:13])-[CH;+0:3]=[CH;+0:4]-[CH;+0:5]1-[CH;+0:9](-[*:10])-[CH;+0:8]2-[*:7]-[CH;+0:6]-1-[O;H0;+0:12]-[O;H0;+0:11]-2.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2. | Kulmacz RJ, Wang LH | 1995 Oct 13 | 7592599 |
| The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | Vecchio AJ, Malkowski MG | 2011 Jun 10 | 21489986 |
| Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. | Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ | 2010 Nov 5 | 20810665 |
| Structural basis of fatty acid substrate binding to cyclooxygenase-2. | Vecchio AJ, Simmons DM, Malkowski MG | 2010 Jul 16 | 20463020 |
| Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. | Kim SF, Huri DA, Snyder SH | 2005 Dec 23 | 16373578 |
| A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. | Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ | 2003 Nov 14 | 12925531 |
| Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. | Ohki S, Ogino N, Yamamoto S, Hayaishi O | 1979 Feb 10 | 104998 |