EC number:1.14.99.22
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.99 Miscellaneous |
| ID: | 1.14.99.22 | ||
|---|---|---|---|
| Description: | Ecdysone 20-monooxygenase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.99.22 |
| BRENDA Enzyme Link: | BRENDA 1.14.99.22 |
| KEGG Enzyme Link: | KEGG1.14.99.22 |
| BioCyc Enzyme Link: | BioCyc 1.14.99.22 |
| ExPASy Enzyme Link: | ExPASy1.14.99.22 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.99.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.99.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.99.22 |
| IntEnz Enzyme Link: | IntEnz 1.14.99.22 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.99.22 |
EC number:1.14.99.22
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14021 | AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[*:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The mechanism of C-20 hydroxylation of alpha-ecdysone in the desert locust, Schistocerca gregaria. | Johnson P, Rees HH | 1977 Dec 15 | 606249 |
| Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.). | Nigg HN, Svoboda JA, Thompson MJ, Dutky SR, Kaplanis JN, Robbins WE | 1976 Apr 15 | 5286 |
| Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase. | Smith SL, Bollenbacher WE, Cooper DY, Schleyer H, Wielgus JJ, Gilbert LI | 1979 Sep | 488526 |
| Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. | Petryk A, Warren JT, Marqués G, Jarcho MP, Gilbert LI, Kahler J, Parvy JP, Li Y, Dauphin-Villemant C, O'Connor MB | 2003 Nov 25 | 14610274 |