EC number:1.14.99.29
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.99 Miscellaneous |
| ID: | 1.14.99.29 |
|---|---|
| Description: | Deoxyhypusine monooxygenase. |
| Alternative Name: |
DOHH. Deoxyhypusine hydroxylase. Deoxyhypusine dioxygenase. |
| Cath: | 3.40.910.10; |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.99.29 |
| BRENDA Enzyme Link: | BRENDA 1.14.99.29 |
| KEGG Enzyme Link: | KEGG1.14.99.29 |
| BioCyc Enzyme Link: | BioCyc 1.14.99.29 |
| ExPASy Enzyme Link: | ExPASy1.14.99.29 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.99.29 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.99.29 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.99.29 |
| IntEnz Enzyme Link: | IntEnz 1.14.99.29 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.99.29 |
EC number:1.14.99.29
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14101 | [eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[O;H0;+0:4]=[O;H0;+0:5]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization. | Abbruzzese A, Park MH, Folk JE | 1986 Mar 5 | 3949761 |
| A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation. | Sievert H, Pällmann N, Miller KK, Hermans-Borgmeyer I, Venz S, Sendoel A, Preukschas M, Schweizer M, Boettcher S, Janiesch PC, Streichert T, Walther R, Hengartner MO, Manz MG, Brümmendorf TH, Bokemeyer C, Braig M, Hauber J, Duncan KE, Balabanov S | 2014 Aug | 24832488 |
| Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton. | Atemnkeng VA, Pink M, Schmitz-Spanke S, Wu XJ, Dong LL, Zhao KH, May C, Laufer S, Langer B, Kaiser A | 2013 | 23505486 |
| A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani. | Chawla B, Kumar RR, Tyagi N, Subramanian G, Srinivasan N, Park MH, Madhubala R | 2012 | 22438895 |
| Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. | Park JH, Aravind L, Wolff EC, Kaevel J, Kim YS, Park MH | 2006 Jan 3 | 16371467 |