EC number:1.14.99.38

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.99 Miscellaneous
ID:1.14.99.38
Description:Cholesterol 25-hydroxylase.
Alternative Name: Cholesterol 25-monooxygenase.
Cath: 1.10.630.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.99.38
BRENDA Enzyme Link: BRENDA 1.14.99.38
KEGG Enzyme Link: KEGG1.14.99.38
BioCyc Enzyme Link: BioCyc 1.14.99.38
ExPASy Enzyme Link: ExPASy1.14.99.38
EC2PDB Enzyme Link: EC2PDB 1.14.99.38
ExplorEnz Enzyme Link: ExplorEnz 1.14.99.38
PRIAM enzyme-specific profiles Link: PRIAM 1.14.99.38
IntEnz Enzyme Link: IntEnz 1.14.99.38
MEDLINE Enzyme Link: MEDLINE 1.14.99.38

EC number:1.14.99.38

MSA:

1.14.99.38;
Phylogenetic Tree:

1.14.99.38;
Uniprot:
M-CSA:
RHEA:21104 AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[*:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:5].[OH2;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The enzymes, regulation, and genetics of bile acid synthesis.Russell DW200312543708
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.Lund EG, Kerr TA, Sakai J, Li WP, Russell DW1998 Dec 189852097
Testosterone regulates 25-hydroxycholesterol production in testicular macrophages.Lukyanenko Y, Chen JJ, Hutson JC2002 Nov12390873
25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro.Chen JJ, Lukyanenko Y, Hutson JC2002 May11967195