EC number:1.14.99.60
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.99 Miscellaneous |
| ID: | 1.14.99.60 |
|---|---|
| Description: | 3-demethoxyubiquinol 3-hydroxylase. |
| Alternative Name: |
5-hydroxylase. 6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.99.60 |
| BRENDA Enzyme Link: | BRENDA 1.14.99.60 |
| KEGG Enzyme Link: | KEGG1.14.99.60 |
| BioCyc Enzyme Link: | BioCyc 1.14.99.60 |
| ExPASy Enzyme Link: | ExPASy1.14.99.60 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.99.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.99.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.99.60 |
| IntEnz Enzyme Link: | IntEnz 1.14.99.60 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.99.60 |
EC number:1.14.99.60
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50908 | a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[O;H0;+0:4]=[O;H0;+0:5]>>[*:1]:[c;H0;+0:2](:[*:3])-[OH;+0:4].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis. | Marbois BN, Clarke CF | 1996 Feb 9 | 8621692 |
| Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. | Tran UC, Marbois B, Gin P, Gulmezian M, Jonassen T, Clarke CF | 2006 Jun 16 | 16624818 |
| A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis. | Stenmark P, Grünler J, Mattsson J, Sindelar PJ, Nordlund P, Berthold DA | 2001 Sep 7 | 11435415 |
| Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. | Vajo Z, King LM, Jonassen T, Wilkin DJ, Ho N, Munnich A, Clarke CF, Francomano CA | 1999 Oct | 10501970 |
| Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene. | Kwon O, Kotsakis A, Meganathan R | 2000 May 15 | 10802164 |