EC number:1.17.4.2

Enzyme

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EC Tree
     1. Oxidoreductases
        1.17 Acting on CH or CH2 groups
            1.17.4 With a disulfide as acceptor
ID:1.17.4.2
Description:Ribonucleoside-triphosphate reductase (thioredoxin).
Alternative Name: Ribonucleotide reductase.
Prosite: PDOC00665;
PDB:
PDBScop
1HK8 8032141; 8044519;
1H7A 8032141; 8044519;
1H79 8032141; 8044519;
3PFL 8029961; 8042340; 8029961; 8042340;
2PFL 8029961; 8042340; 8029961; 8042340;
 » show all
Cath: 1.10.1650.20; 1.10.620.20; 3.20.70.20; 3.30.160.90; 3.30.1620.10; 3.90.1390.10; 2.170.16.10; 3.10.28.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.17.4.2
BRENDA Enzyme Link: BRENDA 1.17.4.2
KEGG Enzyme Link: KEGG1.17.4.2
BioCyc Enzyme Link: BioCyc 1.17.4.2
ExPASy Enzyme Link: ExPASy1.17.4.2
EC2PDB Enzyme Link: EC2PDB 1.17.4.2
ExplorEnz Enzyme Link: ExplorEnz 1.17.4.2
PRIAM enzyme-specific profiles Link: PRIAM 1.17.4.2
IntEnz Enzyme Link: IntEnz 1.17.4.2
MEDLINE Enzyme Link: MEDLINE 1.17.4.2

EC number:1.17.4.2

MSA:

1.17.4.2;
Phylogenetic Tree:

1.17.4.2;
Uniprot:
M-CSA:
RHEA:12701 [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[S;H0;+0:5]-[S;H0;+0:6]-[*:7].[OH2;+0:8]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:8].[*:4]-[SH;+0:5].[*:7]-[SH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii.Goulian M, Beck WS1966 Sep 255924645