EC number:1.17.9.1

Enzyme

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     1. Oxidoreductases
        1.17 Acting on CH or CH2 groups
            1.17.9
ID:1.17.9.1
Description:4-methylphenol dehydrogenase (hydroxylating).
Alternative Name: p-cresol-(acceptor) oxidoreductase (hydroxylating).
p-cresol methylhydroxylase.
4-cresol dehydrogenase (hydroxylating).

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.17.9.1
BRENDA Enzyme Link: BRENDA 1.17.9.1
KEGG Enzyme Link: KEGG1.17.9.1
BioCyc Enzyme Link: BioCyc 1.17.9.1
ExPASy Enzyme Link: ExPASy1.17.9.1
EC2PDB Enzyme Link: EC2PDB 1.17.9.1
ExplorEnz Enzyme Link: ExplorEnz 1.17.9.1
PRIAM enzyme-specific profiles Link: PRIAM 1.17.9.1
IntEnz Enzyme Link: IntEnz 1.17.9.1
MEDLINE Enzyme Link: MEDLINE 1.17.9.1

EC number:1.17.9.1

MSA:

1.17.9.1;
Phylogenetic Tree:

1.17.9.1;
Uniprot:
M-CSA:
RHEA:15141 4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]
RULE(radius=1) [*:1]-[CH3;+0:2].[Cu+2;H0:3].[Cu+2;H0:4].[Cu+2;H0:5].[Cu+2;H0:6].[OH2;+0:7]>>[*:1]-[CH;+0:2]=[O;H0;+0:7].[Cu+;H0:3].[Cu+;H0:4].[Cu+;H0:5].[Cu+;H0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
8 alpha-O-Tyrosyl-FAD: a new form of covalently bound flavin from p-cresol methylhydroxylase.McIntire W, Edmondson DE, Singer TP, Hopper DJ1980 Jul 257391034
The purification and properties of p-cresol-(acceptor) oxidoreductase (hydroxylating), a flavocytochrome from Pseudomonas putida.Hopper DJ, Taylor DG1977 Oct 1588247
Periplasmic location of p-cresol methylhydroxylase in Pseudomonas putida.Hopper DJ, Jones MR, Causer MJ1985 Mar 253920077
Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.Bossert ID, Whited G, Gibson DT, Young LY1989 Jun2722739
Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens.Johannes J, Bluschke A, Jehmlich N, von Bergen M, Boll M2008 Oct18658262
Genes, enzymes, and regulation of para-cresol metabolism in Geobacter metallireducens.Peters F, Heintz D, Johannes J, van Dorsselaer A, Boll M2007 Jul17449613
Stereochemical aspects of the oxidation of 4-ethylphenol by the bacterial enzyme 4-ethylphenol methylenehydroxylase.Reeve CD, Carver MA, Hopper DJ1990 Aug 11697166
Structures of the flavocytochrome p-cresol methylhydroxylase and its enzyme-substrate complex: gated substrate entry and proton relays support the proposed catalytic mechanism.Cunane LM, Chen ZW, Shamala N, Mathews FS, Cronin CN, McIntire WS2000 Jan 1410623531