EC number:1.17.99.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.17 Acting on CH or CH2 groups |
| 1.17.99 With unknown physiological acceptors |
| ID: | 1.17.99.4 |
|---|---|
| Description: | Uracil/thymine dehydrogenase. |
| Alternative Name: |
Uracil-thymine oxidase. Uracil oxidase. Uracil dehydrogenase. |
| Cath: | 3.30.1330.160; 3.30.1330.170; 3.30.1330.180; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.17.99.4 |
| BRENDA Enzyme Link: | BRENDA 1.17.99.4 |
| KEGG Enzyme Link: | KEGG1.17.99.4 |
| BioCyc Enzyme Link: | BioCyc 1.17.99.4 |
| ExPASy Enzyme Link: | ExPASy1.17.99.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.17.99.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.17.99.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.17.99.4 |
| IntEnz Enzyme Link: | IntEnz 1.17.99.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.17.99.4 |
EC number:1.17.99.4
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:22752 | A + H2O + uracil = AH2 + barbiturate + H(+) |
| RULE(radius=1) | |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations. | LARA FJ | 1952 Aug | 14955523 |
| Uracil oxidase and the isolation of barbituric acid from uracil oxidation. | WANG TP, LAMPEN JO | 1952 Feb | 14927672 |
| Metabolism of pyrimidines by a soil bacterium. | WANG TP, LAMPEN JO | 1952 Feb | 14927671 |
| Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes. | HAYAISHI O, KORNBERG A | 1952 May | 12981104 |
| Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase. | Soong CL, Ogawa J, Shimizu S | 2001 Aug 10 | 11485332 |
| RHEA:13469 | A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+) |
| RULE(radius=1) | |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations. | LARA FJ | 1952 Aug | 14955523 |
| Uracil oxidase and the isolation of barbituric acid from uracil oxidation. | WANG TP, LAMPEN JO | 1952 Feb | 14927672 |
| Metabolism of pyrimidines by a soil bacterium. | WANG TP, LAMPEN JO | 1952 Feb | 14927671 |
| Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes. | HAYAISHI O, KORNBERG A | 1952 May | 12981104 |
| Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase. | Soong CL, Ogawa J, Shimizu S | 2001 Aug 10 | 11485332 |