EC number:1.2.1.24
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.24 | ||
|---|---|---|---|
| Description: | Succinate-semialdehyde dehydrogenase (NAD(+)). | ||
| Prosite: | PDOC00068; | ||
| PDB: |
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| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.24 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.24 |
| KEGG Enzyme Link: | KEGG1.2.1.24 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.24 |
| ExPASy Enzyme Link: | ExPASy1.2.1.24 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.24 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.24 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.24 |
| RHEA:13217 | H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase. | Rivett AJ, Tipton KF | 1981 Jun | 7262085 |
| Properties and functions of two succinic-semialdehyde dehydrogenases from Pseudomonas putida. | Sànchez M, Alvarez MA, Balaña R, Garrido-Pertierra A | 1988 Apr 14 | 3355840 |
| Purification and properties of rat brain succinic semialdehyde dehydrogenase. | Cash C, Ciesielski L, Maitre M, Mandel P | 1977 | 19091 |
| Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli. | Fuhrer T, Chen L, Sauer U, Vitkup D | 2007 Nov | 17873044 |
| A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism. | Watanabe S, Kodaki T, Makino K | 2006 Sep 29 | 16835232 |
| Final steps in the catabolism of nicotine. | Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R | 2006 Apr | 16689938 |
| Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. | Busch KB, Fromm H | 1999 Oct | 10517851 |
| Elucidation of the trigonelline degradation pathway reveals previously undescribed enzymes and metabolites. | Perchat N, Saaidi PL, Darii E, Pellé C, Petit JL, Besnard-Gonnet M, de Berardinis V, Dupont M, Gimbernat A, Salanoubat M, Fischer C, Perret A | 2018 May 8 | 29686076 |