EC number:1.2.3.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.3 With oxygen as acceptor |
| ID: | 1.2.3.1 | ||
|---|---|---|---|
| Description: | Aldehyde oxidase. | ||
| Alternative Name: |
Retinal oxidase. Quinoline oxidase. | ||
| Prosite: | PDOC00484; | ||
| PDB: |
|
||
| Cath: | 1.10.150.120; 3.30.365.10; 3.30.390.50; 3.30.43.10; 3.30.43.30; 3.30.465.10; 3.90.1170.50; 3.10.20.30; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.3.1 |
| BRENDA Enzyme Link: | BRENDA 1.2.3.1 |
| KEGG Enzyme Link: | KEGG1.2.3.1 |
| BioCyc Enzyme Link: | BioCyc 1.2.3.1 |
| ExPASy Enzyme Link: | ExPASy1.2.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.3.1 |
| IntEnz Enzyme Link: | IntEnz 1.2.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.3.1 |
| RHEA:22520 | all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2 |
| RULE(radius=1) | [*:1]=[CH;+0:2]-[*:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Retinal oxidase is identical to aldehyde oxidase. | Tomita S, Tsujita M, Ichikawa Y | 1993 Dec 27 | 8262244 |
| Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. | Huang DY, Furukawa A, Ichikawa Y | 1999 Apr 15 | 10190983 |
| Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse. | Terao M, Kurosaki M, Barzago MM, Fratelli M, Bagnati R, Bastone A, Giudice C, Scanziani E, Mancuso A, Tiveron C, Garattini E | 2009 Jan | 18981221 |
| RHEA:16829 | an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2 |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[*:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. | Rashidi MR, Smith JA, Clarke SE, Beedham C | 1997 Jul | 9224775 |
| Purification and characterization of hepatic aldehyde oxidase in male and female mice. | Yoshihara S, Tatsumi K | 1997 Feb 1 | 9015384 |
| Retinal oxidase is identical to aldehyde oxidase. | Tomita S, Tsujita M, Ichikawa Y | 1993 Dec 27 | 8262244 |
| A comparison of the specificities of xanthine oxidase and aldehyde oxidase. | Krenitsky TA, Neil SM, Elion GB, Hitchings GH | 1972 Jun | 5044040 |
| Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1. | Schumann S, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Leimkühler S | 2009 | 19401776 |
| Studies on the mechanism of aldehyde oxidase and xanthine oxidase. | Alfaro JF, Jones JP | 2008 Dec 5 | 18998731 |
| Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690. | Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T | 2003 Dec 5 | 14659539 |
| Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. | Huang DY, Furukawa A, Ichikawa Y | 1999 Apr 15 | 10190983 |