EC number:1.2.4.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.4 With a disulfide as acceptor |
| ID: | 1.2.4.1 |
|---|---|
| Description: | Pyruvate dehydrogenase (acetyl-transferring). |
| Alternative Name: |
Pyruvic dehydrogenase. Pyruvic acid dehydrogenase. acetylating). Pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor- Pyruvate dehydrogenase complex. Pyruvate dehydrogenase (lipoamide). Pyruvate dehydrogenase. Pyruvate decarboxylase. MtPDC (mitochondrial pyruvate dehydrogenase complex). |
| Cath: | 1.20.140.20; 3.30.559.10; 3.30.565.10; 4.10.320.10; 3.40.50.920; 3.40.50.970; 3.60.40.10; 2.30.36.80; 2.40.50.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.4.1 |
| BRENDA Enzyme Link: | BRENDA 1.2.4.1 |
| KEGG Enzyme Link: | KEGG1.2.4.1 |
| BioCyc Enzyme Link: | BioCyc 1.2.4.1 |
| ExPASy Enzyme Link: | ExPASy1.2.4.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.4.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.4.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.4.1 |
| IntEnz Enzyme Link: | IntEnz 1.2.4.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.4.1 |
| RHEA:19189 | [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2 |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[S;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[C;H0;+0:8](=[*:9])-[*:10].[H+;H0:11]>>([*:4]-[S;H0;+0:3]-[C;H0;+0:8](=[*:9])-[*:10].[*:1]-[SH;+0:2]).[*:5]=[C;H0;+0:6]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| [Production of alpha-hydroxyethyl-2-thiamine pyrophosphate with pyruvate oxidase from pig heart muscle]. | SCRIBA P, HOLZER H | 1961 | 13749426 |
| Enzymic mechanisms in the citric acid cycle. | OCHOA S | 1954 | 13158180 |
| Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. | Perham RN | 2000 | 10966480 |