EC number:1.2.4.2

Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.4 With a disulfide as acceptor
ID:1.2.4.2
Description:Oxoglutarate dehydrogenase (succinyl-transferring).
Alternative Name: Oxoglutarate dehydrogenase (lipoamide).
Oxoglutarate dehydrogenase.
Oxoglutarate decarboxylase.
OGDC.
Ketoglutaric dehydrogenase.
Alpha-oxoglutarate dehydrogenase.
Alpha-ketoglutaric dehydrogenase.
Alpha-ketoglutaric acid dehydrogenase.
Alpha-ketoglutarate dehydrogenase.
AKGDH.
succinylating).
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-
2-oxoglutarate: lipoate oxidoreductase.
2-oxoglutarate dehydrogenase.
2-ketoglutarate dehydrogenase.
Cath: 1.10.287.1150; 3.30.559.10; 4.10.320.10; 3.40.50.970; 2.40.50.100; 3.40.50.11610; 3.40.50.12470;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.4.2
BRENDA Enzyme Link: BRENDA 1.2.4.2
KEGG Enzyme Link: KEGG1.2.4.2
BioCyc Enzyme Link: BioCyc 1.2.4.2
ExPASy Enzyme Link: ExPASy1.2.4.2
EC2PDB Enzyme Link: EC2PDB 1.2.4.2
ExplorEnz Enzyme Link: ExplorEnz 1.2.4.2
PRIAM enzyme-specific profiles Link: PRIAM 1.2.4.2
IntEnz Enzyme Link: IntEnz 1.2.4.2
MEDLINE Enzyme Link: MEDLINE 1.2.4.2

EC number:1.2.4.2

MSA:

1.2.4.2;
Phylogenetic Tree:

1.2.4.2;
Uniprot:
M-CSA:
RHEA:12188 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2
RULE(radius=1) [*:1]-[S;H0;+0:2]-[S;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[C;H0;+0:8](=[*:9])-[*:10].[H+;H0:11]>>([*:4]-[S;H0;+0:3]-[C;H0;+0:8](=[*:9])-[*:10].[*:1]-[SH;+0:2]).[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The composition of the ketoglutarate dehydrogenase complex.MASSEY V1960 Mar 1114422131
Enzymic mechanisms in the citric acid cycle.OCHOA S195413158180
Studies on alpha-ketoglutaric oxidase. II. Purification and properties.SANADI DR, LITTLEFIELD JW, BOCK RM1952 May12981117