EC number:1.20.4.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.20 Acting on phosphorus or arsenic in donors |
| 1.20.4 With disulfide as acceptor |
| ID: | 1.20.4.1 |
|---|---|
| Description: | Arsenate reductase (glutaredoxin). |
| Cath: | 3.40.250.10; 3.40.30.10; 3.40.50.2300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.20.4.1 |
| BRENDA Enzyme Link: | BRENDA 1.20.4.1 |
| KEGG Enzyme Link: | KEGG1.20.4.1 |
| BioCyc Enzyme Link: | BioCyc 1.20.4.1 |
| ExPASy Enzyme Link: | ExPASy1.20.4.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.20.4.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.20.4.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.20.4.1 |
| IntEnz Enzyme Link: | IntEnz 1.20.4.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.20.4.1 |
| RHEA:22016 | [glutaredoxin]-dithiol + arsenate + H(+) = [glutaredoxin]-disulfide + arsenite + H2O |
| RULE(radius=1) | [*:1]-[As;H0;+0:2](-[*:3])(-[*:4])=[O;H0;+0:5].[*:6]-[SH;+0:7].[*:8]-[SH;+0:9].[H+;H0:10]>>[*:1]-[As;H0;+0:2](-[*:3])-[*:4].[*:8]-[S;H0;+0:9]-[S;H0;+0:7]-[*:6].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| His-8 lowers the pKa of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773. | Gladysheva T, Liu J, Rosen BP | 1996 Dec 27 | 8969183 |
| Properties of the arsenate reductase of plasmid R773. | Gladysheva TB, Oden KL, Rosen BP | 1994 Jun 14 | 8003492 |
| Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. | Radabaugh TR, Aposhian HV | 2000 Jan | 10649963 |