EC number:1.20.4.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.20 Acting on phosphorus or arsenic in donors |
| 1.20.4 With disulfide as acceptor |
| ID: | 1.20.4.2 |
|---|---|
| Description: | Methylarsonate reductase. |
| Alternative Name: |
MMA(V) reductase. |
| Cath: | 1.20.1050.10; 3.40.30.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.20.4.2 |
| BRENDA Enzyme Link: | BRENDA 1.20.4.2 |
| KEGG Enzyme Link: | KEGG1.20.4.2 |
| BioCyc Enzyme Link: | BioCyc 1.20.4.2 |
| ExPASy Enzyme Link: | ExPASy1.20.4.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.20.4.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.20.4.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.20.4.2 |
| IntEnz Enzyme Link: | IntEnz 1.20.4.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.20.4.2 |
| RHEA:15969 | 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid |
| RULE(radius=1) | [*:1]-[As;H0;+0:2](-[*:3])(-[*:4])=[O;H0;+0:5].[*:6]-[SH;+0:7].[*:8]-[SH;+0:9].[H+;H0:10]>>[*:1]-[As;H0;+0:2](-[*:3])-[*:4].[*:6]-[S;H0;+0:7]-[S;H0;+0:9]-[*:8].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1). | Burmeister C, Lüersen K, Heinick A, Hussein A, Domagalski M, Walter RD, Liebau E | 2008 Feb | 17901115 |
| Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. | Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV | 2001 Aug | 11511179 |
| Identification, characterization, and crystal structure of the Omega class glutathione transferases. | Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J | 2000 Aug 11 | 10783391 |