EC number:1.20.4.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.20 Acting on phosphorus or arsenic in donors |
| 1.20.4 With disulfide as acceptor |
| ID: | 1.20.4.4 |
|---|---|
| Description: | Arsenate reductase (thioredoxin). |
| Cath: | 3.40.250.10; 3.40.30.10; 3.40.50.2300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.20.4.4 |
| BRENDA Enzyme Link: | BRENDA 1.20.4.4 |
| KEGG Enzyme Link: | KEGG1.20.4.4 |
| BioCyc Enzyme Link: | BioCyc 1.20.4.4 |
| ExPASy Enzyme Link: | ExPASy1.20.4.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.20.4.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.20.4.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.20.4.4 |
| IntEnz Enzyme Link: | IntEnz 1.20.4.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.20.4.4 |
| RHEA:43848 | [thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O |
| RULE(radius=1) | [*:1]-[As;H0;+0:2](-[*:3])(-[*:4])=[O;H0;+0:5].[*:6]-[SH;+0:7].[*:8]-[SH;+0:9].[H+;H0:10]>>[*:1]-[As;H0;+0:2](-[*:3])-[*:4].[*:8]-[S;H0;+0:9]-[S;H0;+0:7]-[*:6].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Arsenate reductase of Staphylococcus aureus plasmid pI258. | Ji G, Garber EA, Armes LG, Chen CM, Fuchs JA, Silver S | 1994 Jun 14 | 8003493 |
| All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade. | Messens J, Martins JC, Van Belle K, Brosens E, Desmyter A, De Gieter M, Wieruszeski JM, Willem R, Wyns L, Zegers I | 2002 Jun 25 | 12072565 |
| Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty. | Zegers I, Martins JC, Willem R, Wyns L, Messens J | 2001 Oct | 11573087 |
| The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus. | Messens J, Hayburn G, Desmyter A, Laus G, Wyns L | 1999 Dec 21 | 10606519 |