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1. Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.3 With oxygen as acceptor

ID:

1.21.3.1

Description:

Isopenicillin-N synthase.

Prosite:

PDOC51471;

PDB:

PDB	Scop

Cath:

2.60.120.330;

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UniProtKB Enzyme Link:	UniProtKB 1.21.3.1
BRENDA Enzyme Link:	BRENDA 1.21.3.1
KEGG Enzyme Link:	KEGG1.21.3.1
BioCyc Enzyme Link:	BioCyc 1.21.3.1
ExPASy Enzyme Link:	ExPASy1.21.3.1
EC2PDB Enzyme Link:	EC2PDB 1.21.3.1
ExplorEnz Enzyme Link:	ExplorEnz 1.21.3.1
PRIAM enzyme-specific profiles Link:	PRIAM 1.21.3.1
IntEnz Enzyme Link:	IntEnz 1.21.3.1
MEDLINE Enzyme Link:	MEDLINE 1.21.3.1

RHEA:22428	N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[:4]-[NH;+0:5]-[:6]-[:7]-[CH2;+0:8]-[SH;+0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[:1]-[C;H0;+0:2]1(-[:3])-[:4]-[N;H0;+0:5]2-[:6]-[:7]-[CH;+0:8]-2-[S;H0;+0:9]-1.[OH2;+0:10].[OH2;+0:11]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.	Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE	1997 Jun 19	9194566
Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction.	Ogle JM, Clifton IJ, Rutledge PJ, Elkins JM, Burzlaff NI, Adlington RM, Roach PL, Baldwin JE	2001 Dec	11755401
The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.	Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE	1999 Oct 14	10537113