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1. Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.99 With unknown physiological acceptors

ID:

1.21.99.3

Description:

Thyroxine 5-deiodinase.

Alternative Name:

Type III iodothyronine deiodinase.
Iodothyronine inner ring monodeiodinase.
Iodothyronine 5-deiodinase.
Diiodothyronine 5'-deiodinase.

Prosite:

PDOC00925; PDOC00172;

PDB:

PDB	Scop
4TR4
4TR3

Cath:

3.40.30.10;

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PDB	Click once to unfold,double click to fold. 4TR4; 4TR3;

UniProtKB Enzyme Link:	UniProtKB 1.21.99.3
BRENDA Enzyme Link:	BRENDA 1.21.99.3
KEGG Enzyme Link:	KEGG1.21.99.3
BioCyc Enzyme Link:	BioCyc 1.21.99.3
ExPASy Enzyme Link:	ExPASy1.21.99.3
EC2PDB Enzyme Link:	EC2PDB 1.21.99.3
ExplorEnz Enzyme Link:	ExplorEnz 1.21.99.3
PRIAM enzyme-specific profiles Link:	PRIAM 1.21.99.3
IntEnz Enzyme Link:	IntEnz 1.21.99.3
MEDLINE Enzyme Link:	MEDLINE 1.21.99.3

RHEA:18897	3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine
RULE(radius=1)	[:1]:[cH;+0:2]:[:3].[H+;H0:4].[I-;H0:5]>>[:1]:[c;H0;+0:2](:[:3])-[I;H0;+0:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.	Chopra IJ, Chua Teco GN	1982 Jan	7053997
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference.	Kuiper GG, Klootwijk W, Visser TJ	2003 Jun	12746313
Iodothyronine deiodinases.	Köhrle J	2002	11898402