EC number:1.21.99.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.21 Catalysing the reaction X-H + Y-H = X-Y |
| 1.21.99 With unknown physiological acceptors |
| ID: | 1.21.99.4 | ||
|---|---|---|---|
| Description: | Thyroxine 5'-deiodinase. | ||
| Alternative Name: |
Type II iodothyronine deiodinase. Type I iodothyronine deiodinase. Thyroxine 5-deiodinase. L-thyroxine iodohydrolase (reducing). Iodothyronine outer ring monodeiodinase. Iodothyronine 5'-deiodinase. Diiodothyronine 5'-deiodinase. | ||
| Prosite: | PDOC00925; PDOC00172; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.21.99.4 |
| BRENDA Enzyme Link: | BRENDA 1.21.99.4 |
| KEGG Enzyme Link: | KEGG1.21.99.4 |
| BioCyc Enzyme Link: | BioCyc 1.21.99.4 |
| ExPASy Enzyme Link: | ExPASy1.21.99.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.21.99.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.21.99.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.21.99.4 |
| IntEnz Enzyme Link: | IntEnz 1.21.99.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.21.99.4 |
EC number:1.21.99.4
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:19745 | 3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[H+;H0:4].[I-;H0:5]>>[*:1]:[c;H0;+0:2](:[*:3])-[I;H0;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Iodothyronine deiodinases. | Köhrle J | 2002 | 11898402 |
| Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. | Leonard DM, Stachelek SJ, Safran M, Farwell AP, Kowalik TF, Leonard JL | 2000 Aug 18 | 10829019 |