EC number:1.3.1.44
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.44 |
|---|---|
| Description: | Trans-2-enoyl-CoA reductase (NAD(+)). |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.44 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.44 |
| KEGG Enzyme Link: | KEGG1.3.1.44 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.44 |
| ExPASy Enzyme Link: | ExPASy1.3.1.44 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.44 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.44 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.44 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.44 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.44 |
| RHEA:18177 | a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1.[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism. | Hu K, Zhao M, Zhang T, Zha M, Zhong C, Jiang Y, Ding J | 2013 Jan 1 | 23050861 |
| Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola. | Bond-Watts BB, Weeks AM, Chang MC | 2012 Aug 28 | 22906002 |
| Determination of the crystal structure and active residues of FabV, the enoyl-ACP reductase from Xanthomonas oryzae. | Li H, Zhang X, Bi L, He J, Jiang T | 2011 | 22039545 |
| Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei. | Lu H, Tonge PJ | 2010 Feb 16 | 20055482 |
| Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase. | Zhu L, Lin J, Ma J, Cronan JE, Wang H | 2010 Feb | 19933806 |
| Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase. | Massengo-Tiassé RP, Cronan JE | 2008 Jan 18 | 18032386 |
| A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola. | Tucci S, Martin W | 2007 Apr 17 | 17382934 |
| Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis. | Hoffmeister M, Piotrowski M, Nowitzki U, Martin W | 2005 Feb 11 | 15569691 |