EC number:1.3.1.99
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.99 |
|---|---|
| Description: | Iridoid synthase. |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.99 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.99 |
| KEGG Enzyme Link: | KEGG1.3.1.99 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.99 |
| ExPASy Enzyme Link: | ExPASy1.3.1.99 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.99 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.99 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.99 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.99 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.99 |
| RHEA:35491 | (6E)-8-oxogeranial + H(+) + NADH = (+)-cis-trans-nepetalactol + NAD(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH;+0:8]=[O;H0;+0:9])=[CH;+0:10]-[CH;+0:11]=[O;H0;+0:12].[*:13]-[N;H0;+0:14]1-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[CH2;+0:18]-[CH;+0:19]=[CH;+0:20]-1.[H+;H0:21]>>[*:1]-[CH;+0:2]1-[*:3]-[*:4]-[CH;+0:5]2-[C;H0;+0:6](-[*:7])=[CH;+0:8]-[O;H0;+0:9]-[CH;+0:11](-[OH;+0:12])-[CH;+0:10]-1-2.[*:13]-[n+;H0:14]1:[cH;+0:15]:[c;H0;+0:16](-[*:17]):[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. | Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O'Connor SE | 2012 Dec 6 | 23172143 |
| The seco-iridoid pathway from Catharanthus roseus. | Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D | 2014 Apr 7 | 24710322 |
| RHEA:35395 | (6E)-8-oxogeranial + H(+) + NADPH = (+)-cis-trans-nepetalactol + NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH;+0:8]=[O;H0;+0:9])=[CH;+0:10]-[CH;+0:11]=[O;H0;+0:12].[*:13]-[N;H0;+0:14]1-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[CH2;+0:18]-[CH;+0:19]=[CH;+0:20]-1.[H+;H0:21]>>[*:1]-[CH;+0:2]1-[*:3]-[*:4]-[CH;+0:5]2-[C;H0;+0:6](-[*:7])=[CH;+0:8]-[O;H0;+0:9]-[CH;+0:11](-[OH;+0:12])-[CH;+0:10]-1-2.[*:13]-[n+;H0:14]1:[cH;+0:15]:[c;H0;+0:16](-[*:17]):[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. | Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O'Connor SE | 2012 Dec 6 | 23172143 |
| The seco-iridoid pathway from Catharanthus roseus. | Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D | 2014 Apr 7 | 24710322 |