Enzyme

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     1. Oxidoreductases
        1.3 Acting on the CH-CH group of donors
            1.3.3 With oxygen as acceptor
ID:1.3.3.4
Description:Protoporphyrinogen oxidase.
Alternative Name: Protoporphyrinogenase.
Protoporphyrinogen IX oxidase.
Cath: 1.10.3110.10; 1.10.3110.20; 3.50.50.60; 3.90.660.20;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.3.3.4
BRENDA Enzyme Link: BRENDA 1.3.3.4
KEGG Enzyme Link: KEGG1.3.3.4
BioCyc Enzyme Link: BioCyc 1.3.3.4
ExPASy Enzyme Link: ExPASy1.3.3.4
EC2PDB Enzyme Link: EC2PDB 1.3.3.4
ExplorEnz Enzyme Link: ExplorEnz 1.3.3.4
PRIAM enzyme-specific profiles Link: PRIAM 1.3.3.4
IntEnz Enzyme Link: IntEnz 1.3.3.4
MEDLINE Enzyme Link: MEDLINE 1.3.3.4
MSA:

1.3.3.4;

Phylogenetic Tree:

1.3.3.4;

Uniprot:
M-CSA:
RHEA:25576 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX
RULE(radius=1) ([*:1]-[CH2;+0:2]-[*:3]:[nH;+0:4]:[*:5]-[CH2;+0:6]-[*:7].[*:8]-[CH2;+0:9]-[*:10]:[nH;+0:11]:[*:12]-[CH2;+0:13]-[*:14]).[O;H0;+0:15]=[O;H0;+0:16].[O;H0;+0:17]=[O;H0;+0:18].[O;H0;+0:19]=[O;H0;+0:20]>>([*:1]:[cH;+0:2]:[*:3]:[n;H0;+0:4]:[*:5]:[cH;+0:6]:[*:7].[*:8]:[cH;+0:9]:[*:10]:[n;H0;+0:11]:[*:12]:[cH;+0:13]:[*:14]).[OH;+0:15]-[OH;+0:16].[OH;+0:17]-[OH;+0:18].[OH;+0:19]-[OH;+0:20]
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References

TitleAuthorsDatePubMed ID
Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus.Dailey TA, Dailey HA1998 May 299593705
Molecular cloning and characterization of a cDNA that encodes protoporphyrinogen oxidase of Arabidopsis thaliana.Narita S, Tanaka R, Ito T, Okada K, Taketani S, Inokuchi H1996 Dec 58982084
Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme.Dailey HA, Dailey TA1996 Apr 128621504
Cloning, sequence, and expression of mouse protoporphyrinogen oxidase.Dailey TA, Dailey HA, Meissner P, Prasad AR1995 Dec 208554330
Expression of a cloned protoporphyrinogen oxidase.Dailey TA, Meissner P, Dailey HA1994 Jan 148288631
Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells.Taketani S, Yoshinaga T, Furukawa T, Kohno H, Tokunaga R, Nishimura K, Inokuchi H1995 Jun 17607249
Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin.Ferreira GC, Dailey HA1988 Mar 12451512
Quantitative structural insight into human variegate porphyria disease.Wang B, Wen X, Qin X, Wang Z, Tan Y, Shen Y, Xi Z2013 Apr 2623467411
Structural insight into human variegate porphyria disease.Qin X, Tan Y, Wang L, Wang Z, Wang B, Wen X, Yang G, Xi Z, Shen Y2011 Feb21048046
Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis.Qin X, Sun L, Wen X, Yang X, Tan Y, Jin H, Cao Q, Zhou W, Xi Z, Shen Y2010 Apr19944166
Site-directed mutagenesis and computational study of the Y366 active site in Bacillus subtilis protoporphyrinogen oxidase.Sun L, Wen X, Tan Y, Li H, Yang X, Zhao Y, Wang B, Cao Q, Niu C, Xi Z2009 Sep19266155
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis.Koch M, Breithaupt C, Kiefersauer R, Freigang J, Huber R, Messerschmidt A2004 Apr 2115057273
Functional studies of mutations in the human protoporphyrinogen oxidase gene in variegate porphyria.Morgan RR, da SV, Puy H, Deybach JC, Elder GH2002 Feb11929051
Molecular characterization and subcellular localization of protoporphyrinogen oxidase in spinach chloroplasts.Che FS, Watanabe N, Iwano M, Inokuchi H, Takayama S, Yoshida S, Isogai A2000 Sep10982422