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1. Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.7 With an iron-sulfur protein as acceptor

ID:	1.3.7.11
Description:	2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
Alternative Name:	2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor).
Cath:	3.30.9.10; 3.50.50.60;

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UniProtKB Enzyme Link:	UniProtKB 1.3.7.11
BRENDA Enzyme Link:	BRENDA 1.3.7.11
KEGG Enzyme Link:	KEGG1.3.7.11
BioCyc Enzyme Link:	BioCyc 1.3.7.11
ExPASy Enzyme Link:	ExPASy1.3.7.11
EC2PDB Enzyme Link:	EC2PDB 1.3.7.11
ExplorEnz Enzyme Link:	ExplorEnz 1.3.7.11
PRIAM enzyme-specific profiles Link:	PRIAM 1.3.7.11
IntEnz Enzyme Link:	IntEnz 1.3.7.11
MEDLINE Enzyme Link:	MEDLINE 1.3.7.11

RHEA:54324	a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 16 oxidized [2Fe-2S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]
RULE(radius=1)	([:1]-[CH2;+0:2]-[CH;+0:3](-[:4])-[:5]-[:6]-[CH2;+0:7]-[CH;+0:8](-[:9])-[:10]-[:11]-[CH2;+0:12]-[CH;+0:13](-[:14])-[:15]-[:16]-[CH2;+0:17]-[CH;+0:18](-[:19])-[:20].[:21]-[CH;+0:22](-[:23]-[:24]-[CH2;+0:25]-[CH;+0:26](-[:27])-[:28]-[:29]-[CH2;+0:30]-[CH;+0:31](-[:32])-[:33]-[:34]-[CH2;+0:35]-[CH;+0:36](-[:37])-[:38])-[CH2;+0:39]-[:40])>>([:21]-[C;H0;+0:22](-[:23]-[:24]-[CH;+0:25]=[C;H0;+0:26](-[:27])-[:28]-[:29]-[CH;+0:30]=[C;H0;+0:31](-[:32])-[:33]-[:34]-[CH;+0:35]=[C;H0;+0:36](-[:37])-[:38])=[CH;+0:39]-[:40].[:1]-[CH;+0:2]=[C;H0;+0:3](-[:4])-[:5]-[:6]-[CH;+0:7]=[C;H0;+0:8](-[:9])-[:10]-[:11]-[CH;+0:12]=[C;H0;+0:13](-[:14])-[:15]-[:16]-[CH;+0:17]=[C;H0;+0:18](-[:19])-[:20])
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.	Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H	2014 Jan	24214941
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.	Sato S, Murakami M, Yoshimura T, Hemmi H	2008 Jun	18375567
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.	Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H	2007 Feb	17288560

RHEA:36159	2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 16 oxidized [2Fe-2S]-[ferredoxin] = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]
RULE(radius=1)	([:1]-[CH2;+0:2]-[CH;+0:3](-[:4])-[:5]-[:6]-[CH2;+0:7]-[CH;+0:8](-[:9])-[:10]-[:11]-[CH2;+0:12]-[CH;+0:13](-[:14])-[:15]-[:16]-[CH2;+0:17]-[CH;+0:18](-[:19])-[:20].[:21]-[CH;+0:22](-[:23]-[:24]-[CH2;+0:25]-[CH;+0:26](-[:27])-[:28]-[:29]-[CH2;+0:30]-[CH;+0:31](-[:32])-[:33]-[:34]-[CH2;+0:35]-[CH;+0:36](-[:37])-[:38])-[CH2;+0:39]-[:40])>>([:21]-[C;H0;+0:22](-[:23]-[:24]-[CH;+0:25]=[C;H0;+0:26](-[:27])-[:28]-[:29]-[CH;+0:30]=[C;H0;+0:31](-[:32])-[:33]-[:34]-[CH;+0:35]=[C;H0;+0:36](-[:37])-[:38])=[CH;+0:39]-[:40].[:1]-[CH;+0:2]=[C;H0;+0:3](-[:4])-[:5]-[:6]-[CH;+0:7]=[C;H0;+0:8](-[:9])-[:10]-[:11]-[CH;+0:12]=[C;H0;+0:13](-[:14])-[:15]-[:16]-[CH;+0:17]=[C;H0;+0:18](-[:19])-[:20])
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.	Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H	2014 Jan	24214941
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.	Sato S, Murakami M, Yoshimura T, Hemmi H	2008 Jun	18375567
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.	Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H	2007 Feb	17288560