EC number:1.3.8.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.8 With a flavin as acceptor |
| ID: | 1.3.8.12 |
|---|---|
| Description: | (2S)-methylsuccinyl-CoA dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.8.12 |
| BRENDA Enzyme Link: | BRENDA 1.3.8.12 |
| KEGG Enzyme Link: | KEGG1.3.8.12 |
| BioCyc Enzyme Link: | BioCyc 1.3.8.12 |
| ExPASy Enzyme Link: | ExPASy1.3.8.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.8.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.8.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.8.12 |
| IntEnz Enzyme Link: | IntEnz 1.3.8.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.8.12 |
| RHEA:45028 | (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[CH3;+0:5].[*:6]:[c;H0;+0:7]1:[n;H0;+0:8]:[*:9]:[*:10]:[n;H0;+0:11](-[*:12]):[c;H0;+0:13]-1:[n;H0;+0:14]:[*:15].[H+;H0:16]>>[*:1]-[C;H0;+0:2](-[CH3;+0:5])=[CH;+0:3]-[*:4].[*:6]:[c;H0;+0:7]1:[c;H0;+0:13](:[nH;+0:14]:[*:15])-[N;H0;+0:11](-[*:12])-[*:10]:[*:9]-[NH;+0:8]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family. | Schwander T, McLean R, Zarzycki J, Erb TJ | 2018 Feb 2 | 29275330 |
| (2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. | Erb TJ, Fuchs G, Alber BE | 2009 Sep | 19703103 |