EC number:1.3.8.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.8 With a flavin as acceptor |
| ID: | 1.3.8.2 |
|---|---|
| Description: | 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming). |
| Alternative Name: |
Dehydrosqualene desaturase. 4,4'-diapophytoene desaturase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.8.2 |
| BRENDA Enzyme Link: | BRENDA 1.3.8.2 |
| KEGG Enzyme Link: | KEGG1.3.8.2 |
| BioCyc Enzyme Link: | BioCyc 1.3.8.2 |
| ExPASy Enzyme Link: | ExPASy1.3.8.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.8.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.8.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.8.2 |
| IntEnz Enzyme Link: | IntEnz 1.3.8.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.8.2 |
| RHEA:42800 | 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2 |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[CH2;+0:6]-[CH2;+0:7]-[*:8]=[*:9]-[CH2;+0:10]-[CH2;+0:11]-[*:12]).[*:13]-[n;H0;+0:14]1:[*:15]:[*:16]:[n;H0;+0:17]:[c;H0;+0:18](:[*:19])-[c;H0;+0:20]:1:[n;H0;+0:21]:[*:22]>>([*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[CH;+0:6]=[CH;+0:7]-[*:8]=[*:9]-[CH;+0:10]=[CH;+0:11]-[*:12]).[*:13]-[N;H0;+0:14]1-[*:15]:[*:16]-[NH;+0:17]-[c;H0;+0:18](:[*:19]):[c;H0;+0:20]-1:[nH;+0:21]:[*:22] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus. | Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Götz F | 1994 Dec | 8002598 |
| Carotenoid production in Bacillus subtilis achieved by metabolic engineering. | Yoshida K, Ueda S, Maeda I | 2009 Nov | 19618272 |
| Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde. | Tao L, Schenzle A, Odom JM, Cheng Q | 2005 Jun | 15933032 |
| Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. | Raisig A, Sandmann G | 2001 Sep 28 | 11566453 |
| 4,4'-diapophytoene desaturase: catalytic properties of an enzyme from the C(30) carotenoid pathway of Staphylococcus aureus. | Raisig A, Sandmann G | 1999 Oct | 10498735 |
| RHEA:31391 | 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2 |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4]=[*:5]-[CH2;+0:6]-[CH2;+0:7]-[*:8].[*:9]-[CH2;+0:10]-[CH2;+0:11]-[*:12]=[*:13]-[CH2;+0:14]-[CH2;+0:15]-[*:16]).[*:17]-[n;H0;+0:18]1:[*:19]:[*:20]:[n;H0;+0:21]:[c;H0;+0:22](:[*:23])-[c;H0;+0:24]:1:[n;H0;+0:25]:[*:26]>>([*:1]-[CH;+0:2]=[CH;+0:3]-[*:4]=[*:5]-[CH;+0:6]=[CH;+0:7]-[*:8].[*:9]-[CH;+0:10]=[CH;+0:11]-[*:12]=[*:13]-[CH;+0:14]=[CH;+0:15]-[*:16]).[*:17]-[N;H0;+0:18]1-[*:19]:[*:20]-[NH;+0:21]-[c;H0;+0:22](:[*:23]):[c;H0;+0:24]-1:[nH;+0:25]:[*:26] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus. | Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Götz F | 1994 Dec | 8002598 |
| Carotenoid production in Bacillus subtilis achieved by metabolic engineering. | Yoshida K, Ueda S, Maeda I | 2009 Nov | 19618272 |
| Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde. | Tao L, Schenzle A, Odom JM, Cheng Q | 2005 Jun | 15933032 |
| Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. | Raisig A, Sandmann G | 2001 Sep 28 | 11566453 |
| 4,4'-diapophytoene desaturase: catalytic properties of an enzyme from the C(30) carotenoid pathway of Staphylococcus aureus. | Raisig A, Sandmann G | 1999 Oct | 10498735 |