EC number:1.3.8.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.8 With a flavin as acceptor |
| ID: | 1.3.8.4 | ||
|---|---|---|---|
| Description: | Isovaleryl-CoA dehydrogenase. | ||
| Prosite: | PDOC00070; | ||
| PDB: |
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| Cath: | 1.10.540.10; 1.20.140.10; 2.40.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.8.4 |
| BRENDA Enzyme Link: | BRENDA 1.3.8.4 |
| KEGG Enzyme Link: | KEGG1.3.8.4 |
| BioCyc Enzyme Link: | BioCyc 1.3.8.4 |
| ExPASy Enzyme Link: | ExPASy1.3.8.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.8.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.8.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.8.4 |
| IntEnz Enzyme Link: | IntEnz 1.3.8.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.8.4 |
| RHEA:31063 | 3-methylbutanoyl-CoA + FAD + H(+) = 3-methylbut-2-enoyl-CoA + FADH2 |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]:[c;H0;+0:7]1:[n;H0;+0:8]:[*:9]:[*:10]:[n;H0;+0:11](-[*:12]):[c;H0;+0:13]-1:[n;H0;+0:14]:[*:15].[H+;H0:16]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]:[c;H0;+0:7]1:[c;H0;+0:13](:[nH;+0:14]:[*:15])-[N;H0;+0:11](-[*:12])-[*:10]:[*:9]-[NH;+0:8]-1 |
| Reaction |  |
| Core-to-Core |
| RHEA:12276 | 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]:[c;H0;+0:7]1:[n;H0;+0:8]:[*:9]:[*:10]:[n;H0;+0:11](-[*:12]):[c;H0;+0:13]-1:[n;H0;+0:14]:[*:15].[H+;H0:16]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]:[c;H0;+0:7]1:[c;H0;+0:13](:[nH;+0:14]:[*:15])-[N;H0;+0:11](-[*:12])-[*:10]:[*:9]-[NH;+0:8]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family. | Rozen R, Vockley J, Zhou L, Milos R, Willard J, Fu K, Vicanek C, Low-Nang L, Torban E, Fournier B | 1994 Nov 15 | 7698750 |
| Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase. | Mohsen AW, Vockley J | 1995 Aug 15 | 7640268 |
| Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria. | Ikeda Y, Tanaka K | 1983 Jan 25 | 6401713 |
| Isovaleric acidemia: a new genetic defect of leucine metabolism. | Tanaka K, Budd MA, Efron ML, Isselbacher KJ | 1966 Jul | 5229850 |
| Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A. | BACHHAWAT BK, ROBINSON WG, COON MJ | 1956 Apr | 13319276 |