EC number:1.3.8.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.8 With a flavin as acceptor |
| ID: | 1.3.8.7 |
|---|---|
| Description: | Medium-chain acyl-CoA dehydrogenase. |
| Alternative Name: |
General acyl CoA dehydrogenase. Fatty-acyl-CoA dehydrogenase. Fatty acyl coenzyme A dehydrogenase. Acyl dehydrogenase. Acyl coenzyme A dehydrogenase. Acyl CoA dehydrogenase. |
| Cath: | 1.10.540.10; 1.20.140.10; 2.40.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.8.7 |
| BRENDA Enzyme Link: | BRENDA 1.3.8.7 |
| KEGG Enzyme Link: | KEGG1.3.8.7 |
| BioCyc Enzyme Link: | BioCyc 1.3.8.7 |
| ExPASy Enzyme Link: | ExPASy1.3.8.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.8.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.8.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.8.7 |
| IntEnz Enzyme Link: | IntEnz 1.3.8.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.8.7 |
| RHEA:14477 | a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[n;H0;+0:7]:[*:8]:[*:9]:[n;H0;+0:10](-[*:11]):[c;H0;+0:12]-1:[n;H0;+0:13]:[*:14].[H+;H0:15]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[c;H0;+0:12](:[nH;+0:13]:[*:14])-[N;H0;+0:10](-[*:11])-[*:9]:[*:8]-[NH;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of activation of acyl-CoA substrates by medium chain acyl-CoA dehydrogenase: interaction of the thioester carbonyl with the flavin adenine dinucleotide ribityl side chain. | Engst S, Vock P, Wang M, Kim JJ, Ghisla S | 1999 Jan 5 | 9890906 |
| Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. | Kim JJ, Wang M, Paschke R | 1993 Aug 15 | 8356049 |
| Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. | Ikeda Y, Okamura-Ikeda K, Tanaka K | 1985 Jan 25 | 3968063 |
| Acyl-CoA dehydrogenases and acyl-CoA oxidases. Structural basis for mechanistic similarities and differences. | Kim JJ, Miura R | 2004 Feb | 14728675 |
| On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase. | CRANE FL, MII S, HAUGE JG, GREEN DE, BEINERT H | 1956 Feb | 13295224 |
| Flavoproteins involved in the first oxidative step of the fatty acid cycle. | CRANE FL, HAUGE JG, BEINERT H | 1955 Jun | 13239683 |