EC number:1.3.98.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.98 With other, known, physiological acceptors |
| ID: | 1.3.98.4 |
|---|---|
| Description: | 5a,11a-dehydrotetracycline reductase. |
| Alternative Name: |
Dehydrooxytetracycline dehydrogenase. 12-dehydrotetracycline reductase. 12-dehydrotetracycline dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.98.4 |
| BRENDA Enzyme Link: | BRENDA 1.3.98.4 |
| KEGG Enzyme Link: | KEGG1.3.98.4 |
| BioCyc Enzyme Link: | BioCyc 1.3.98.4 |
| ExPASy Enzyme Link: | ExPASy1.3.98.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.98.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.98.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.98.4 |
| IntEnz Enzyme Link: | IntEnz 1.3.98.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.98.4 |
| RHEA:50392 | H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[OH;+0:3])=[C;H0;+0:4](-[*:5])-[CH;+0:6](-[*:7])-[*:8].[*:9]-[n;H0;+0:10]1:[*:11]:[*:12]:[cH;+0:13]:[c;H0;+0:14](:[*:15])-[c;H0;+0:16]:1:[n;H0;+0:17]:[*:18].[H+;H0:19]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[C;H0;+0:4](-[*:5])=[C;H0;+0:6](-[*:7])-[*:8].[*:9]-[N;H0;+0:10]1-[*:11]:[*:12]-[CH2;+0:13]-[c;H0;+0:14](:[*:15]):[c;H0;+0:16]-1:[nH;+0:17]:[*:18] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. | Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y | 2013 May 15 | 23621493 |
| RHEA:50384 | H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[OH;+0:3])=[C;H0;+0:4](-[*:5])-[CH;+0:6](-[*:7])-[*:8].[*:9]-[n;H0;+0:10]1:[*:11]:[*:12]:[cH;+0:13]:[c;H0;+0:14](:[*:15])-[c;H0;+0:16]:1:[n;H0;+0:17]:[*:18].[H+;H0:19]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[C;H0;+0:4](-[*:5])=[C;H0;+0:6](-[*:7])-[*:8].[*:9]-[N;H0;+0:10]1-[*:11]:[*:12]-[CH2;+0:13]-[c;H0;+0:14](:[*:15]):[c;H0;+0:16]-1:[nH;+0:17]:[*:18] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. | Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y | 2013 May 15 | 23621493 |