EC number:1.3.99.36
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.99 With unknown physiological acceptors |
| ID: | 1.3.99.36 |
|---|---|
| Description: | Cypemycin cysteine dehydrogenase (decarboxylating). |
| Alternative Name: |
Cypemycin decarboxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.99.36 |
| BRENDA Enzyme Link: | BRENDA 1.3.99.36 |
| KEGG Enzyme Link: | KEGG1.3.99.36 |
| BioCyc Enzyme Link: | BioCyc 1.3.99.36 |
| ExPASy Enzyme Link: | ExPASy1.3.99.36 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.99.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.99.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.99.36 |
| IntEnz Enzyme Link: | IntEnz 1.3.99.36 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.99.36 |
EC number:1.3.99.36
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10904 | [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide |
| RULE(radius=1) | ([*:1]-[CH;+0:2](-[CH2;+0:3]-[SH;+0:4])-[C;H0;+0:5](=[*:6])-[OH;+0:7].[*:8]-[SH;+0:9])>>[*:1]-[CH;+0:2]=[CH;+0:3]-[S;H0;+0:9]-[*:8].[*:6]=[C;H0;+0:5]=[O;H0;+0:7].[SH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. | Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA | 2013 Jan | 23165928 |
| Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. | Claesen J, Bibb M | 2010 Sep 14 | 20805503 |