EC number:1.4.1.21
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.21 |
|---|---|
| Description: | Aspartate dehydrogenase. |
| Alternative Name: |
NADP(+)-dependent aspartate dehydrogenase. NADH(2)-dependent aspartate dehydrogenase. NAD-dependent aspartate dehydrogenase. |
| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.21 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.21 |
| KEGG Enzyme Link: | KEGG1.4.1.21 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.21 |
| ExPASy Enzyme Link: | ExPASy1.4.1.21 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.21 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.21 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.21 |
| RHEA:11788 | H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. | Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L | 2003 Mar 7 | 12496312 |
| RHEA:11784 | H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. | Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L | 2003 Mar 7 | 12496312 |