EC number:1.4.3.13
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.3 With oxygen as acceptor |
| ID: | 1.4.3.13 | ||||
|---|---|---|---|---|---|
| Description: | Protein-lysine 6-oxidase. | ||||
| Alternative Name: |
Lysyl oxidase. | ||||
| Prosite: | PDOC00716; | ||||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.3.13 |
| BRENDA Enzyme Link: | BRENDA 1.4.3.13 |
| KEGG Enzyme Link: | KEGG1.4.3.13 |
| BioCyc Enzyme Link: | BioCyc 1.4.3.13 |
| ExPASy Enzyme Link: | ExPASy1.4.3.13 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.3.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.3.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.3.13 |
| IntEnz Enzyme Link: | IntEnz 1.4.3.13 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.3.13 |
| RHEA:24544 | H2O + L-lysyl-[protein] + O2 = [protein]-(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH2;+0:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[CH;+0:2]=[O;H0;+0:6].[NH3;+0:3].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Properties of highly purified lysyl oxidase from embryonic chick cartilage. | Stassen FL | 1976 Jun 7 | 7318 |
| Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates. | Kagan HM, Williams MA, Williamson PR, Anderson JM | 1984 Sep 25 | 6147351 |
| Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta. | Harris ED, Gonnerman WA, Savage JE, O'Dell BL | 1974 Apr 25 | 4838158 |
| Induction of lysyl oxidase with copper. Properties of an in vitro system. | Rayton JK, Harris ED | 1979 Feb 10 | 33171 |
| Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells. | Xu L, Go EP, Finney J, Moon H, Lantz M, Rebecchi K, Desaire H, Mure M | 2013 Feb 22 | 23319596 |
| Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor. | Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V | 2010 Jul 2 | 20439985 |
| The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin. | Kim YM, Kim EC, Kim Y | 2011 Jan | 20306300 |
| A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. | Palamakumbura AH, Trackman PC | 2002 Jan 15 | 11779117 |