EC number:1.4.3.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.3 With oxygen as acceptor |
| ID: | 1.4.3.2 |
|---|---|
| Description: | L-amino-acid oxidase. |
| Alternative Name: |
Ophio-amino-acid oxidase. |
| Cath: | 1.10.405.10; 1.20.1440.240; 3.20.20.70; 3.30.9.10; 3.50.50.60; 3.90.660.10; 3.90.660.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.3.2 |
| BRENDA Enzyme Link: | BRENDA 1.4.3.2 |
| KEGG Enzyme Link: | KEGG1.4.3.2 |
| BioCyc Enzyme Link: | BioCyc 1.4.3.2 |
| ExPASy Enzyme Link: | ExPASy1.4.3.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.3.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.3.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.3.2 |
| IntEnz Enzyme Link: | IntEnz 1.4.3.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.3.2 |
| RHEA:13781 | an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:7].[NH3;+0:4].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom. | Torii S, Naito M, Tsuruo T | 1997 Apr 4 | 9083096 |
| On the reaction mechanism of Crotalus adamanteus L-amino acid oxidase. | Massey V, Curti B | 1967 Mar 25 | 6067195 |
| [Kinetic studies on the reaction mechanism of L-amino acid oxidase from Neuraspora crassa]. | Luppa D, Aurich H | 1971 | 4260304 |
| Crystal structure of LAAO from Calloselasma rhodostoma with an L-phenylalanine substrate: insights into structure and mechanism. | Moustafa IM, Foster S, Lyubimov AY, Vrielink A | 2006 Dec 15 | 17046020 |
| Apoptotic effect in the glioma cells induced by specific protein extracted from Okinawa Habu (Trimeresurus flavoviridis) venom in relation to oxidative stress. | Sun LK, Yoshii Y, Hyodo A, Tsurushima H, Saito A, Harakuni T, Li YP, Kariya K, Nozaki M, Morine N | 2003 Apr | 12650671 |
| Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with L-amino acid oxidase activity. | Torii S, Yamane K, Mashima T, Haga N, Yamamoto K, Fox JW, Naito M, Tsuruo T | 2000 Mar 28 | 10727211 |
| Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data. | Souza DH, Eugenio LM, Fletcher JE, Jiang MS, Garratt RC, Oliva G, Selistre-de-Araujo HS | 1999 Aug 15 | 10441379 |