EC number:1.4.3.21
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.3 With oxygen as acceptor |
| ID: | 1.4.3.21 |
|---|---|
| Description: | Primary-amine oxidase. |
| Alternative Name: |
Copper amine oxidase. CAO. Benzylamine oxidase. Amine oxidase (copper-containing). Amine oxidase. |
| Cath: | 1.10.405.10; 1.20.5.1360; 3.10.450.40; 3.30.457.10; 3.50.50.60; 3.90.660.10; 2.70.98.20; 3.10.129.10; |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.3.21 |
| BRENDA Enzyme Link: | BRENDA 1.4.3.21 |
| KEGG Enzyme Link: | KEGG1.4.3.21 |
| BioCyc Enzyme Link: | BioCyc 1.4.3.21 |
| ExPASy Enzyme Link: | ExPASy1.4.3.21 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.3.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.3.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.3.21 |
| IntEnz Enzyme Link: | IntEnz 1.4.3.21 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.3.21 |
| RHEA:35107 | 3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH2;+0:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[CH;+0:2]=[O;H0;+0:6].[NH3;+0:3].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate. | Rankin LD, Bodenmiller DM, Partridge JD, Nishino SF, Spain JC, Spiro S | 2008 Sep | 18658270 |
| RHEA:25265 | 2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH2;+0:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[CH;+0:2]=[O;H0;+0:6].[NH3;+0:3].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Visualization of dioxygen bound to copper during enzyme catalysis. | Wilmot CM, Hajdu J, McPherson MJ, Knowles PF, Phillips SE | 1999 Nov 26 | 10576737 |
| RHEA:16153 | an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH2;+0:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[CH;+0:2]=[O;H0;+0:6].[NH3;+0:3].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini. | Lee Y, Sayre LM | 1998 Jul 31 | 9677370 |
| Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone. | Wilce MC, Dooley DM, Freeman HC, Guss JM, Matsunami H, McIntire WS, Ruggiero CE, Tanizawa K, Yamaguchi H | 1997 Dec 23 | 9405045 |
| Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects. | Lyles GA | 1996 Mar | 8920635 |
| Cloning and molecular analysis of the pea seedling copper amine oxidase. | Tipping AJ, McPherson MJ | 1995 Jul 14 | 7622512 |
| Microbial oxidation of amines. Distribution, purification and properties of two primary-amine oxidases from the yeast Candida boidinii grown on amines as sole nitrogen source. | Haywood GW, Large PJ | 1981 Oct 1 | 7337701 |
| Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. | Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA | 2005 Aug | 16046623 |
| Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do. | O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF | 2004 Jan | 14697905 |
| Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue. | Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF | 2002 Aug 1 | 11985492 |
| Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase. | Andrés N, Lizcano JM, Rodríguez MJ, Romera M, Unzeta M, Mahy N | 2001 Feb | 11156689 |
| Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions. | Houen G | 1999 | 10668504 |