EC number:1.4.3.23
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.3 With oxygen as acceptor |
| ID: | 1.4.3.23 |
|---|---|
| Description: | 7-chloro-L-tryptophan oxidase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.3.23 |
| BRENDA Enzyme Link: | BRENDA 1.4.3.23 |
| KEGG Enzyme Link: | KEGG1.4.3.23 |
| BioCyc Enzyme Link: | BioCyc 1.4.3.23 |
| ExPASy Enzyme Link: | ExPASy1.4.3.23 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.3.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.3.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.3.23 |
| IntEnz Enzyme Link: | IntEnz 1.4.3.23 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.3.23 |
| RHEA:49024 | L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[NH;+0:4].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of Violacein, Structure and Function of l-Tryptophan Oxidase VioA from Chromobacterium violaceum. | Füller JJ, Röpke R, Krausze J, Rennhack KE, Daniel NP, Blankenfeldt W, Schulz S, Jahn D, Moser J | 2016 Sep 16 | 27466367 |
| Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core. | Hoshino T | 2011 Sep | 21779844 |
| Biochemical characterization and substrate specificity of the gene cluster for biosyntheses of K-252a and its analogs by in vitro heterologous expression system of Escherichia coli. | Chiu HT, Lin YC, Lee MN, Chen YL, Wang MS, Lai CC | 2009 Oct | 19756309 |
| Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function. | Shinoda K, Hasegawa T, Sato H, Shinozaki M, Kuramoto H, Takamiya Y, Sato T, Nikaidou N, Watanabe T, Hoshino T | 2007 Oct 28 | 17925955 |
| In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. | Balibar CJ, Walsh CT | 2006 Dec 26 | 17176066 |
| Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. | Sánchez C, Braña AF, Méndez C, Salas JA | 2006 Aug | 16874749 |
| Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. | Howard-Jones AR, Walsh CT | 2005 Dec 6 | 16313168 |
| Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. | Nishizawa T, Aldrich CC, Sherman DH | 2005 Mar | 15743957 |
| RHEA:27302 | 7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[NH;+0:4].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. | Howard-Jones AR, Walsh CT | 2005 Dec 6 | 16313168 |
| Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. | Nishizawa T, Aldrich CC, Sherman DH | 2005 Mar | 15743957 |
| Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243. | Onaka H, Taniguchi S, Igarashi Y, Furumai T | 2003 Jan | 12619684 |