EC number:1.4.4.2

Enzyme

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     1. Oxidoreductases
        1.4 Acting on the CH-NH2 group of donors
            1.4.4 With a disulfide as acceptor
ID:1.4.4.2
Description:Glycine dehydrogenase (aminomethyl-transferring).
Alternative Name: Glycine-cleavage complex P-protein.
Glycine dehydrogenase (decarboxylating).
Glycine decarboxylase.
Glycine cleavage system P-protein.
Cath: 1.10.10.10; 1.20.120.530; 3.30.1360.120; 3.30.390.30; 3.30.70.140; 3.30.70.1400; 4.10.820.20; 3.40.640.10; 3.50.50.60; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.4.4.2
BRENDA Enzyme Link: BRENDA 1.4.4.2
KEGG Enzyme Link: KEGG1.4.4.2
BioCyc Enzyme Link: BioCyc 1.4.4.2
ExPASy Enzyme Link: ExPASy1.4.4.2
EC2PDB Enzyme Link: EC2PDB 1.4.4.2
ExplorEnz Enzyme Link: ExplorEnz 1.4.4.2
PRIAM enzyme-specific profiles Link: PRIAM 1.4.4.2
IntEnz Enzyme Link: IntEnz 1.4.4.2
MEDLINE Enzyme Link: MEDLINE 1.4.4.2

EC number:1.4.4.2

MSA:

1.4.4.2;
Phylogenetic Tree:

1.4.4.2;
Uniprot:
M-CSA:
RHEA:24304 glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
RULE(radius=1) [*:1]-[S;H0;+0:2]-[S;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[CH2;+0:8]-[*:9].[H+;H0:10]>>([*:4]-[S;H0;+0:3]-[CH2;+0:8]-[*:9].[*:1]-[SH;+0:2]).[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ2005 Feb15642479
Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.Perham RN200010966480
The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein.Hiraga K, Kikuchi G1980 Dec 257440563