EC number:1.5.3.13
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.3 With oxygen as acceptor |
| ID: | 1.5.3.13 |
|---|---|
| Description: | N(1)-acetylpolyamine oxidase. |
| Alternative Name: |
Polyamine oxidase. PAO. |
| Cath: | 3.50.50.60; 3.90.660.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.3.13 |
| BRENDA Enzyme Link: | BRENDA 1.5.3.13 |
| KEGG Enzyme Link: | KEGG1.5.3.13 |
| BioCyc Enzyme Link: | BioCyc 1.5.3.13 |
| ExPASy Enzyme Link: | ExPASy1.5.3.13 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.3.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.3.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.3.13 |
| IntEnz Enzyme Link: | IntEnz 1.5.3.13 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.3.13 |
| RHEA:25800 | H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:1]-[CH;+0:2]=[O;H0;+0:7].[*:4]-[NH2;+0:3].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. | Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA | 2008 Aug | 18583528 |
| Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion. | Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R | 2006 Aug | 16778015 |
| Crystal structures of Fms1 and its complex with spermine reveal substrate specificity. | Huang Q, Liu Q, Hao Q | 2005 May 13 | 15843025 |
| Purification and characterization of polyamine oxidase from Ascaris suum. | Müller S, Walter RD | 1992 Apr 1 | 1567380 |
| Yeast Fms1 is a FAD-utilizing polyamine oxidase. | Landry J, Sternglanz R | 2003 Apr 11 | 12670477 |
| Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. | Wu T, Yankovskaya V, McIntire WS | 2003 Jun 6 | 12660232 |
| Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. | Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW | 2003 Feb 15 | 12477380 |
| RHEA:25804 | H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:1]-[CH;+0:2]=[O;H0;+0:7].[*:4]-[NH2;+0:3].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A putative peroxisomal polyamine oxidase, AtPAO4, is involved in polyamine catabolism in Arabidopsis thaliana. | Kamada-Nobusada T, Hayashi M, Fukazawa M, Sakakibara H, Nishimura M | 2008 Sep | 18703589 |
| Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. | Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA | 2008 Aug | 18583528 |
| Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. | Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr | 2008 Jun | 18422650 |
| Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion. | Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R | 2006 Aug | 16778015 |
| Purification and characterization of polyamine oxidase from Ascaris suum. | Müller S, Walter RD | 1992 Apr 1 | 1567380 |
| Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. | Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr | 2003 May 16 | 12727196 |
| Yeast Fms1 is a FAD-utilizing polyamine oxidase. | Landry J, Sternglanz R | 2003 Apr 11 | 12670477 |
| Heterologous expression and characterization of mouse spermine oxidase. | Cervelli M, Polticelli F, Federico R, Mariottini P | 2003 Feb 14 | 12458219 |
| Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. | Murray-Stewart T, Wang Y, Devereux W, Casero RA Jr | 2002 Dec 15 | 12398765 |
| Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. | Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW | 2002 Nov 1 | 12141946 |
| RHEA:25808 | H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:1]-[CH;+0:2]=[O;H0;+0:7].[*:4]-[NH2;+0:3].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. | Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA | 2008 Aug | 18583528 |
| Purification and characterization of polyamine oxidase from Ascaris suum. | Müller S, Walter RD | 1992 Apr 1 | 1567380 |
| Yeast Fms1 is a FAD-utilizing polyamine oxidase. | Landry J, Sternglanz R | 2003 Apr 11 | 12670477 |
| Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. | Murray-Stewart T, Wang Y, Devereux W, Casero RA Jr | 2002 Dec 15 | 12398765 |
| Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. | Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW | 2002 Nov 1 | 12141946 |
| Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. | Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA Jr | 2001 Jul 15 | 11454677 |
| RHEA:25812 | H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:1]-[CH;+0:2]=[O;H0;+0:7].[*:4]-[NH2;+0:3].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. | Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA | 2008 Aug | 18583528 |
| Biochemistry of mammalian peroxisomes revisited. | Wanders RJ, Waterham HR | 2006 | 16756494 |
| Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity. | Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA Jr | 2005 Jul | 15791459 |
| Purification and characterization of polyamine oxidase from Ascaris suum. | Müller S, Walter RD | 1992 Apr 1 | 1567380 |
| Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines. | Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J | 2005 Feb 25 | 15611107 |
| Yeast Fms1 is a FAD-utilizing polyamine oxidase. | Landry J, Sternglanz R | 2003 Apr 11 | 12670477 |
| Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. | Wu T, Yankovskaya V, McIntire WS | 2003 Jun 6 | 12660232 |
| Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. | Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW | 2003 Feb 15 | 12477380 |
| RHEA:25868 | H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH2;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6].[OH2;+0:7]>>[*:4]-[CH;+0:3]=[O;H0;+0:7].[*:1]-[NH2;+0:2].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Yeast Fms1 is a FAD-utilizing polyamine oxidase. | Landry J, Sternglanz R | 2003 Apr 11 | 12670477 |
| Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. | Wu T, Yankovskaya V, McIntire WS | 2003 Jun 6 | 12660232 |
| Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. | Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW | 2003 Feb 15 | 12477380 |