EC number:1.5.99.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.99 With unknown physiological acceptors |
| ID: | 1.5.99.4 |
|---|---|
| Description: | Nicotine dehydrogenase. |
| Alternative Name: |
L-nicotine oxidase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.99.4 |
| BRENDA Enzyme Link: | BRENDA 1.5.99.4 |
| KEGG Enzyme Link: | KEGG1.5.99.4 |
| BioCyc Enzyme Link: | BioCyc 1.5.99.4 |
| ExPASy Enzyme Link: | ExPASy1.5.99.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.99.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.99.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.99.4 |
| IntEnz Enzyme Link: | IntEnz 1.5.99.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.99.4 |
| RHEA:42352 | (R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2 |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[OH2;+0:4]>>[*:1]:[c;H0;+0:2](:[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine. | HOCHSTEIN LI, RITTENBERG SC | 1959 Jan | 13610912 |
| RHEA:14769 | (S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2 |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[OH2;+0:4]>>[*:1]:[c;H0;+0:2](:[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The purification and properties of nicotine oxidase. | Hochstein LI, Dalton BP | 1967 May 16 | 4962139 |
| The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine. | HOCHSTEIN LI, RITTENBERG SC | 1959 Jan | 13610912 |
| The bacterial oxidation of nicotinic acid. | BEHRMAN EJ, STANIER RY | 1957 Oct | 13475371 |
| Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans. | Decker K, Bleeg H | 1965 Aug 24 | 5849820 |
| Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans. | Grether-Beck S, Igloi GL, Pust S, Schilz E, Decker K, Brandsch R | 1994 Sep | 7815950 |