EC number:1.7.3.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.7 Acting on other nitrogenous compounds as donors |
| 1.7.3 With oxygen as acceptor |
| ID: | 1.7.3.1 |
|---|---|
| Description: | Nitroalkane oxidase. |
| Alternative Name: |
Nitroethane reductase. Nitroethane oxidase. NAO. |
| Cath: | 1.10.540.10; 1.20.140.10; 3.20.20.70; 2.40.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.7.3.1 |
| BRENDA Enzyme Link: | BRENDA 1.7.3.1 |
| KEGG Enzyme Link: | KEGG1.7.3.1 |
| BioCyc Enzyme Link: | BioCyc 1.7.3.1 |
| ExPASy Enzyme Link: | ExPASy1.7.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.7.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.7.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.7.3.1 |
| IntEnz Enzyme Link: | IntEnz 1.7.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.7.3.1 |
| RHEA:50772 | H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[N+;H0:3](=[*:4])-[*:5].[O;H0;+0:6]=[O;H0;+0:7].[OH2;+0:8]>>[*:1]-[CH;+0:2]=[O;H0;+0:8].[*:4]=[N;H0;+0:3]-[*:5].[OH;+0:6]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of nitroalkane oxidase from Fusarium oxysporum. | Kido T, Hashizume K, Soda K | 1978 Jan | 22538 |
| Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase. | Tormos JR, Taylor AB, Daubner SC, Hart PJ, Fitzpatrick PF | 2010 Jun 22 | 20481475 |
| Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase. | Valley MP, Tichy SE, Fitzpatrick PF | 2005 Feb 23 | 15713081 |
| Inactivation of nitroalkane oxidase upon mutation of the active site base and rescue with a deprotonated substrate. | Valley MP, Fitzpatrick PF | 2003 Jul 23 | 12862464 |
| RHEA:26490 | a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[N+;H0:4](=[*:5])-[*:6].[O;H0;+0:7]=[O;H0;+0:8].[OH2;+0:9]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:9].[*:5]=[N;H0;+0:4]-[*:6].[OH;+0:7]-[OH;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nitroalkane oxidase: Structure and mechanism. | Fitzpatrick PF | 2017 Oct 15 | 28529198 |
| Purification and properties of nitroalkane oxidase from Fusarium oxysporum. | Kido T, Hashizume K, Soda K | 1978 Jan | 22538 |
| Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase. | Tormos JR, Taylor AB, Daubner SC, Hart PJ, Fitzpatrick PF | 2010 Jun 22 | 20481475 |
| Crystal structures of intermediates in the nitroalkane oxidase reaction. | Héroux A, Bozinovski DM, Valley MP, Fitzpatrick PF, Orville AM | 2009 Apr 21 | 19265437 |
| Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase. | Fitzpatrick PF, Bozinovski DM, Héroux A, Shaw PG, Valley MP, Orville AM | 2007 Dec 4 | 17994768 |
| Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase. | Valley MP, Tichy SE, Fitzpatrick PF | 2005 Feb 23 | 15713081 |
| Inactivation of nitroalkane oxidase upon mutation of the active site base and rescue with a deprotonated substrate. | Valley MP, Fitzpatrick PF | 2003 Jul 23 | 12862464 |
| RHEA:20976 | a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[N+;H0:3](=[*:4])-[*:5].[O;H0;+0:6]=[O;H0;+0:7].[OH2;+0:8]>>[*:1]-[CH;+0:2]=[O;H0;+0:8].[*:4]=[N;H0;+0:3]-[*:5].[OH;+0:6]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nitroalkane oxidase: Structure and mechanism. | Fitzpatrick PF | 2017 Oct 15 | 28529198 |
| Purification and properties of nitroalkane oxidase from Fusarium oxysporum. | Kido T, Hashizume K, Soda K | 1978 Jan | 22538 |
| Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase. | Tormos JR, Taylor AB, Daubner SC, Hart PJ, Fitzpatrick PF | 2010 Jun 22 | 20481475 |
| Crystal structures of intermediates in the nitroalkane oxidase reaction. | Héroux A, Bozinovski DM, Valley MP, Fitzpatrick PF, Orville AM | 2009 Apr 21 | 19265437 |
| Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase. | Fitzpatrick PF, Bozinovski DM, Héroux A, Shaw PG, Valley MP, Orville AM | 2007 Dec 4 | 17994768 |
| Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase. | Valley MP, Tichy SE, Fitzpatrick PF | 2005 Feb 23 | 15713081 |
| Inactivation of nitroalkane oxidase upon mutation of the active site base and rescue with a deprotonated substrate. | Valley MP, Fitzpatrick PF | 2003 Jul 23 | 12862464 |