Enzyme

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EC Tree
     1. Oxidoreductases
        1.8 Acting on a sulfur group of donors
            1.8.3 With oxygen as acceptor
ID:1.8.3.7
Description:Formylglycine-generating enzyme.
Alternative Name: Sulfatase-modifying factor 1.
C-alpha-formylglycine-generating enzyme 1.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.8.3.7
BRENDA Enzyme Link: BRENDA 1.8.3.7
KEGG Enzyme Link: KEGG1.8.3.7
BioCyc Enzyme Link: BioCyc 1.8.3.7
ExPASy Enzyme Link: ExPASy1.8.3.7
EC2PDB Enzyme Link: EC2PDB 1.8.3.7
ExplorEnz Enzyme Link: ExplorEnz 1.8.3.7
PRIAM enzyme-specific profiles Link: PRIAM 1.8.3.7
IntEnz Enzyme Link: IntEnz 1.8.3.7
MEDLINE Enzyme Link: MEDLINE 1.8.3.7
MSA:

1.8.3.7;

Phylogenetic Tree:

1.8.3.7;

Uniprot:
M-CSA:
RHEA:51152 [sulfatase]-L-cysteine + 2 a thiol + O2 = [sulfatase]-3-oxo-L-alanine + an organic disulfide + H(+) + H2O + hydrogen sulfide
RULE(radius=1) [*:1]-[CH2;+0:2]-[SH;+0:3].[*:4]-[SH;+0:5].[*:6]-[SH;+0:7].[O;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[CH;+0:2]=[O;H0;+0:8].[*:6]-[S;H0;+0:7]-[S;H0;+0:5]-[*:4].[OH2;+0:9].[SH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine.Dierks T, Miech C, Hummerjohann J, Schmidt B, Kertesz MA, von Figura K1998 Oct 29748219
Conversion of cysteine to formylglycine: a protein modification in the endoplasmic reticulum.Dierks T, Schmidt B, von Figura K1997 Oct 289342345
Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme.Meury M, Knop M, Seebeck FP2017 Jul 328544744
Copper is a Cofactor of the Formylglycine-Generating Enzyme.Knop M, Dang TQ, Jeschke G, Seebeck FP2017 Jan 1727862795
In Vitro Reconstitution of Formylglycine-Generating Enzymes Requires Copper(I).Knop M, Engi P, Lemnaru R, Seebeck FP2015 Oct 1226403223
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.Holder PG, Jones LC, Drake PM, Barfield RM, Bañas S, de Hart GW, Baker J, Rabuka D2015 Jun 1925931126
Function and structure of a prokaryotic formylglycine-generating enzyme.Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi CR2008 Jul 1818390551
A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme.Roeser D, Preusser-Kunze A, Schmidt B, Gasow K, Wittmann JG, Dierks T, von Figura K, Rudolph MG2006 Jan 316368756
Molecular characterization of the human Calpha-formylglycine-generating enzyme.Preusser-Kunze A, Mariappan M, Schmidt B, Gande SL, Mutenda K, Wenzel D, von Figura K, Dierks T2005 Apr 1515657036