EC number:1.8.4.14
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.8 Acting on a sulfur group of donors |
| 1.8.4 With a disulfide as acceptor |
| ID: | 1.8.4.14 |
|---|---|
| Description: | L-methionine (R)-S-oxide reductase. |
| Alternative Name: |
FRMsr. Free-methionine (R)-S-oxide reductase. Free met-R-(o) reductase. |
| Cath: | 3.30.450.40; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.8.4.14 |
| BRENDA Enzyme Link: | BRENDA 1.8.4.14 |
| KEGG Enzyme Link: | KEGG1.8.4.14 |
| BioCyc Enzyme Link: | BioCyc 1.8.4.14 |
| ExPASy Enzyme Link: | ExPASy1.8.4.14 |
| EC2PDB Enzyme Link: | EC2PDB 1.8.4.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.8.4.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.8.4.14 |
| IntEnz Enzyme Link: | IntEnz 1.8.4.14 |
| MEDLINE Enzyme Link: | MEDLINE 1.8.4.14 |
| RHEA:21260 | [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[*:3].[*:4]-[S;H0;+0:5]-[S;H0;+0:6]-[*:7].[OH2;+0:8]>>[*:1]-[S;H0;+0:2](-[*:3])=[O;H0;+0:8].[*:7]-[SH;+0:6].[*:4]-[SH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. | Aachmann FL, Kwak GH, Del Conte R, Kim HY, Gladyshev VN, Dikiy A | 2011 Nov | 21989933 |
| Substrate binding in free methionine-R-sulfoxide reductase. | Gruez A, Libiad M, Boschi-Muller S, Branlant G | 2010 Sep 24 | 20851894 |
| Structural and kinetic analysis of free methionine-R-sulfoxide reductase from Staphylococcus aureus: conformational changes during catalysis and implications for the catalytic and inhibitory mechanisms. | Bong SM, Kwak GH, Moon JH, Lee KS, Kim HS, Kim HY, Chi YM | 2010 Aug 6 | 20504774 |
| Cysteine-125 is the catalytic residue of Saccharomyces cerevisiae free methionine-R-sulfoxide reductase. | Kwak GH, Kim MJ, Kim HY | 2010 May 7 | 20382110 |
| Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. | Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN | 2009 Feb 13 | 19049972 |
| A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide. | Etienne F, Spector D, Brot N, Weissbach H | 2003 Jan 10 | 12504094 |