EC number:1.8.4.8

Enzyme

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     1. Oxidoreductases
        1.8 Acting on a sulfur group of donors
            1.8.4 With a disulfide as acceptor
ID:1.8.4.8
Description:Phosphoadenylyl-sulfate reductase (thioredoxin).
Alternative Name: Thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase.
Thioredoxin:3'-phospho-adenylylsulfate reductase.
Phosphoadenosine-phosphosulfate reductase.
PAPS sulfotransferase.
PAPS reductase, thioredoxin-dependent.
PAPS reductase.
PAdoPS reductase.
3'-phosphoadenylylsulfate reductase.
Cath: 3.40.50.620;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.8.4.8
BRENDA Enzyme Link: BRENDA 1.8.4.8
KEGG Enzyme Link: KEGG1.8.4.8
BioCyc Enzyme Link: BioCyc 1.8.4.8
ExPASy Enzyme Link: ExPASy1.8.4.8
EC2PDB Enzyme Link: EC2PDB 1.8.4.8
ExplorEnz Enzyme Link: ExplorEnz 1.8.4.8
PRIAM enzyme-specific profiles Link: PRIAM 1.8.4.8
IntEnz Enzyme Link: IntEnz 1.8.4.8
MEDLINE Enzyme Link: MEDLINE 1.8.4.8

EC number:1.8.4.8

MSA:

1.8.4.8;
Phylogenetic Tree:

1.8.4.8;
Uniprot:
M-CSA:
RHEA:11724 [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S;H0;+0:4]-[S;H0;+0:5]-[*:6].[*:7]=[S;H0;+0:8](-[*:9])-[OH;+0:10].[H+;H0:11].[H+;H0:12]>>[*:1]-[O;H0;+0:2]-[S;H0;+0:8](=[*:7])(-[*:9])=[O;H0;+0:10].[*:3]-[SH;+0:4].[*:6]-[SH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Reaction mechanism of thioredoxin: 3'-phospho-adenylylsulfate reductase investigated by site-directed mutagenesis.Berendt U, Haverkamp T, Prior A, Schwenn JD1995 Oct 17588765